Suzhen Wang

TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.

TL;DR: Several novel SMGs and re-annotated mutational signatures that are linked to immunotherapy response or resistance and an immune subtype was found to exhibit favorable prognoses, and further studies are required to validate these findings.

TL;DR: Wang et al. as discussed by the authors investigated the association of atypical cadherin 1 (FAT1) mutations with ICI response and outcome and found that patients with FAT1 mutations had a significantly improved survival outcome than those wild-type patients.

TL;DR: It is uncovered that HSPG2 mutations were predictive of a better ICI response and associated with preferable immunogenicity, which may be considered as a genomic determinant to customize biotherapy strategies.

TL;DR: In this paper , the authors investigated the immunological characteristics of Turner syndrome (TS) patients with different X-chromosomal origins and found that the most enriched signals were immune response-related.