F
Faith Hollingsworth
Researcher at University of Texas MD Anderson Cancer Center
Publications - 5
Citations - 1185
Faith Hollingsworth is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Glioma & Cleavage (embryo). The author has an hindex of 4, co-authored 5 publications receiving 966 citations. Previous affiliations of Faith Hollingsworth include University of Texas at Austin.
Papers
More filters
Journal ArticleDOI
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P.L. Bhat,Veerakumar Balasubramaniyan,Brian Vaillant,Ravesanker Ezhilarasan,Karlijn Hummelink,Faith Hollingsworth,Khalida Wani,Lindsey Heathcock,Johanna D. James,Lindsey D. Goodman,Siobhan Conroy,Lihong Long,Nina Lelic,Suzhen Wang,Joy Gumin,Divya Raj,Yoshinori Kodama,Aditya Raghunathan,Adriana Olar,Kaushal Joshi,Christopher E. Pelloski,Amy B. Heimberger,Se Hoon Kim,Daniel P. Cahill,Ganesh Rao,Wilfred F. A. den Dunnen,Hendrikus Boddeke,Heidi S. Phillips,Ichiro Nakano,Frederick F. Lang,Howard Colman,Erik P. Sulman,Kenneth Aldape +32 more
TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.
Journal ArticleDOI
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
Krishna P.L. Bhat,Krishna P.L. Bhat,Katrina Salazar,Katrina Salazar,Veerakumar Balasubramaniyan,Veerakumar Balasubramaniyan,Veerakumar Balasubramaniyan,Khalida Wani,Lindsey Heathcock,Faith Hollingsworth,Johanna D. James,Joy Gumin,Kristin Diefes,Se Hoon Kim,Se Hoon Kim,Alice Turski,Yasaman Azodi,Yuhui Yang,Tiffany Doucette,Howard Colman,Erik P. Sulman,Frederick F. Lang,Ganesh Rao,Sjef Copray,Brian Vaillant,Kenneth Aldape +25 more
TL;DR: These studies uncover a direct role for TAZ and TEAD in driving the MES differentiation of malignant glioma.
Journal ArticleDOI
Caspase-3 Cleavage Links δ-Catenin to the Novel Nuclear Protein ZIFCAT
Dongmin Gu,Nam K. Tonthat,Nam K. Tonthat,Moonsup Lee,Moonsup Lee,Hong Ji,Krishna P. Bhat,Faith Hollingsworth,Kenneth Aldape,Maria A. Schumacher,Maria A. Schumacher,Thomas P. Zwaka,Pierre D. McCrea,Pierre D. McCrea +13 more
TL;DR: It is found that cleavage of δ-catenin both abolishes its association with cadherins and impairs its ability to modulate small GTPases, and Interestingly, 817–1314 possesses a conserved putative nuclear localization signal that may facilitate the nuclear targeting ofδ-Catenin in defined contexts.
Journal Article
Taz as a regulator of mesenchymal transformation and clinical aggressiveness in gliomas
K. Salazar,Brian Vaillant,K. Wani,Faith Hollingsworth,Kristin Diefes,T. Doucette,J. Gumin,D. Patel,Frederick F. Lang,G. Rao,Krishna P. Bhat,Kenneth Aldape,Veerakumar Balasubramaniyan,J. J. A. Mooij,Se Hoon Kim +14 more
TL;DR: In this paper, the authors identify TAZ (transcriptional coactivator with PDZ-binding motif) as a transcription co-activator whose expression level is tightly associated with the mesenchymal change.
Proceedings ArticleDOI
Abstract B27: TAZ as a regulator of mesenchymal transformation and clinical aggressiveness in gliomas
Katrina Salazar,Veerakumar Balasubramaniyan,Brian Vaillant,Faith Hollingsworth,Kristin Diefes,Dimple Patel,Krishna P. Bhat,Kenneth Aldape +7 more
TL;DR: TAZ (transcriptional coactivator with PDZ-binding motif) is identified as a transcription co-activator whose expression level is tightly associated with the mesenchymal change (elevated TAZ is positively associated with higher expression of key mesenchyme genes).