S
Svenja Debey
Researcher at University of Cologne
Publications - 13
Citations - 1925
Svenja Debey is an academic researcher from University of Cologne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 10, co-authored 13 publications receiving 1848 citations. Previous affiliations of Svenja Debey include University of Pennsylvania & University of Bonn.
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Journal ArticleDOI
Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine
Marc Beyer,Matthias Kochanek,Matthias Kochanek,Kamruz Darabi,Kamruz Darabi,Alexey Popov,Alexey Popov,Markus Jensen,Markus Jensen,Elmar Endl,Elmar Endl,PA Knolle,PA Knolle,Roman K. Thomas,Roman K. Thomas,Michael von Bergwelt-Baildon,Michael von Bergwelt-Baildon,Svenja Debey,Svenja Debey,Michael Hallek,Michael Hallek,Joachim L. Schultze,Joachim L. Schultze +22 more
TL;DR: Most surprisingly, in the majority of patients with CLL treated with fludarabine-containing therapy regimens the inhibitory function of Treg cells was decreased or even abrogated.
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Salicylic Acid–Independent ENHANCED DISEASE SUSCEPTIBILITY1 Signaling in Arabidopsis Immunity and Cell Death Is Regulated by the Monooxygenase FMO1 and the Nudix Hydrolase NUDT7
Michael Bartsch,Enrico Gobbato,Paweł Bednarek,Svenja Debey,Joachim L. Schultze,Jaqueline Bautor,Jane E. Parker +6 more
TL;DR: Two new immune regulators are defined through analysis of corresponding Arabidopsis loss-of-function insertion mutants, and it is found that SA antagonizes initiation of cell death and stunting of growth in nudt7 mutants.
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CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.
Michael von Bergwelt-Baildon,Alexey Popov,Tomo Saric,Jens Chemnitz,Sabine Classen,Marc S. Stoffel,F. Fiore,Udo Roth,Marc Beyer,Svenja Debey,Claudia Wickenhauser,Franz-Georg Hanisch,Joachim L. Schultze +12 more
TL;DR: PGE2 is suggested to be a mediator of early events during induction of immune tolerance in cancer by demonstrating a concomitant induction of IDO and secretion of soluble CD25 after DC maturation in the presence of PGE2.
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Comparison of different isolation techniques prior gene expression profiling of blood derived cells: impact on physiological responses, on overall expression and the role of different cell types.
Svenja Debey,U. Schoenbeck,Martin Hellmich,Birgit S. Gathof,R Pillai,Thomas Zander,Joachim L. Schultze +6 more
TL;DR: It is concluded that for large clinical studies, it is crucial to reduce maximally the time to RNA isolation to optimize clinical studies applying gene expression analysis of peripheral blood to exploit drug responses and to better understand changes associated with disease.
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Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection
Alexey Popov,Zeinab Abdullah,Claudia Wickenhauser,Tomo Saric,Julia Driesen,Franz-Georg Hanisch,Eugen Domann,Emma Lloyd Raven,Oliver Dehus,Corinna Hermann,Daniela Eggle,Svenja Debey,Trinad Chakraborty,Martin Krönke,Olaf Utermöhlen,Joachim L. Schultze +15 more
TL;DR: It is shown in human listeriosis that DCs expressing indoleamine 2,3-dioxygenase (IDO), together with macrophages, are major cellular components of suppurative granulomas in vivo and in vitro that IDO induction is TNF-alpha dependent.