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Eugen Domann

Researcher at University of Giessen

Publications -  148
Citations -  11466

Eugen Domann is an academic researcher from University of Giessen. The author has contributed to research in topics: Listeria monocytogenes & Listeria. The author has an hindex of 50, co-authored 143 publications receiving 10681 citations. Previous affiliations of Eugen Domann include University of Würzburg.

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An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement.

TL;DR: This new form of silver called NanoSilver was free of in vitro cytotoxicity and showed high effectiveness against multiresistant bacteria and may have a high interest in joint arthroplasty.
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A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.

TL;DR: It is demonstrated that ActA–EVH1 binding is a paradigm for a novel class of eukaryotic protein–protein interactions involving a proline‐rich ligand that is clearly different from those described for SH3 and WW/WWP domains.
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A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.

TL;DR: Within the cytoplasm of the infected cells, the mutant strain grew as microcolonies, was unable to accumulate actin following escape from the phagocytic compartment and was incapable of infecting adjacent cells, demonstrating that the capacity to move intracellularly and spread intercellularly is a key determinant of L.monocytogenes virulence.
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Coordinate regulation of virulence genes in Listeria monocytogenes requires the product of the prfA gene.

TL;DR: The concomitant loss of multiple characteristics such as production of LisA, Pic, Mpl, and loss of virulence in a mouse infection model is the result of a mutation in a single gene and demonstrates that the prfA gene product is a positive regulator of multiple virulence determinants in L. monocytogenes.