S
Svitlana Shpyleva
Researcher at National Center for Toxicological Research
Publications - 23
Citations - 1173
Svitlana Shpyleva is an academic researcher from National Center for Toxicological Research. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 14, co-authored 22 publications receiving 1015 citations. Previous affiliations of Svitlana Shpyleva include Food and Drug Administration & University of Arkansas for Medical Sciences.
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Journal ArticleDOI
Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
Igor P. Pogribny,Jody Filkowski,Volodymyr Tryndyak,Andrey Golubov,Svitlana Shpyleva,Olga Kovalchuk +5 more
TL;DR: The results suggest that dysregulated miRNA expression may underlie the abnormal functioning of critical cellular processes associated with the cisplatin‐resistant phenotype.
Journal ArticleDOI
Role of ferritin alterations in human breast cancer cells.
Svitlana Shpyleva,Volodymyr Tryndyak,Olga Kovalchuk,Athena Starlard-Davenport,Vasyl F. Chekhun,Frederick A. Beland,Igor P. Pogribny +6 more
TL;DR: P perturbations in ferritin levels are associated with the progression of breast cancer toward a more advanced malignant phenotype and miR-200b-induced down-regulation of ferritIn was associated with an increased sensitivity of the MDA-MB-231 cells to the chemotherapeutic agent doxorubicin.
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Complex epigenetic regulation of Engrailed-2 ( EN-2 ) homeobox gene in the autism cerebellum
TL;DR: The results suggest that the normal EN-2 downregulation that signals Purkinje cell maturation during late prenatal and early-postnatal development may not have occurred in some individuals with autism and that the postnatal persistence of EN- 2 overexpression may contribute to autism cerebellar abnormalities.
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MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
Iryna Kindrat,Iryna Kindrat,Volodymyr Tryndyak,Aline de Conti,Svitlana Shpyleva,Thilak K. Mudalige,Tetyana Kobets,Anna M. Erstenyuk,Frederick A. Beland,Igor P. Pogribny +9 more
TL;DR: The results indicated that the increase in levels of TFRC in human HCC cells andhuman HCC tissue samples may be attributed, in part, to a post-transcriptional mechanism mediated by a down-regulation of miR-152, which suggests that mi R-152-specific targeting ofTFRC may provide a selective anticancer therapeutic approach for the treatment of HCC.
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Overexpression of LINE-1 Retrotransposons in Autism Brain
TL;DR: The results indicated that L1 expression was significantly elevated in the autism cerebellum but not in BA9, BA22, or BA24, and the binding of repressive MeCP2 and histone H3K9me3 to L1 sequences was significantly lower in autism Cerebellum suggesting that relaxation of epigenetic repression may have contributed to increased expression.