Frederick A. Beland

TL;DR: A review of the botany, physical and chemical properties, and biological activities of the Aloe vera plant finds that it contains multiple constituents with potential biological and toxicological activities, yet the active components elude definition.

TL;DR: Results from carcinogenicity bioassays with malachite green have been equivocal; however, it appears to act as a tumor promoter, perhaps because of its ability to induce the formation of reactive oxygen species.

TL;DR: The tumorigenicity of two coal tar mixtures was compared and indicated that the benzo[a]pyrene in the coal tar diets could be responsible for the forestomach tumors, while the lung and liver tumors appeared to be due to other genotoxic components contained within thecoal tar mixture, whereas the small intestine tumors resulted from chemically-induced cell proliferation that occurred at high doses of coal tar.

TL;DR: DNA adduct formation from AA treatment in adult mice showed a supralinear dose-response relationship, consistent with saturation of oxidative metabolism at higher doses, which increases the understanding of the mutagenic potential of GA and provides further evidence for a genotoxic mechanism in AA carcinogenesis.