S
Sydney Aten
Researcher at Ohio State University
Publications - 22
Citations - 408
Sydney Aten is an academic researcher from Ohio State University. The author has contributed to research in topics: Circadian rhythm & Suprachiasmatic nucleus. The author has an hindex of 7, co-authored 18 publications receiving 236 citations. Previous affiliations of Sydney Aten include The Ohio State University Wexner Medical Center.
Papers
More filters
Journal ArticleDOI
Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome
Katelin F. Hansen,Kensuke Sakamoto,Sydney Aten,Kaitlin H. Snider,Jacob Loeser,Andrea M. Hesse,Chloe E. Page,Carl Pelz,J. Simon C. Arthur,Soren Impey,Karl Obrietan +10 more
TL;DR: A role for the miR-132/-212 gene locus as a key regulator of cognitive capacity is firmly established and these data indicate that these miRNAs do not exhibit strongly overlapping mRNA targeting profiles, thus indicating that these two genes may function in a complex, nonredundant manner to shape the transcriptional profile of the CNS.
Journal ArticleDOI
Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits.
Kaitlin H. Snider,Heather Dziema,Sydney Aten,Jacob Loeser,Frances E. Norona,Kari R. Hoyt,Karl Obrietan +6 more
TL;DR: The use of a clock knockout strategy in which the essential circadian timing gene Bmal1 was selectively deleted from excitatory forebrain neurons, whilst the SCN clock remained intact, suggests that forebrain clock timing plays a critical role in shaping the efficiency of learning and memory retrieval over the circadian day.
Journal ArticleDOI
The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition.
TL;DR: A brief overview of the expression and functional effects of the miR-132/212 gene locus in forebrain circuits of the CNS is provided, and a recent publication that explored the contributions of miR/212 to cognition and to transcriptome regulation is discussed.
Journal ArticleDOI
Ultrastructural view of astrocyte arborization, astrocyte-astrocyte and astrocyte-synapse contacts, intracellular vesicle-like structures, and mitochondrial network
Sydney Aten,Conrad M. Kiyoshi,Emily P. Arzola,Jeremy A. Patterson,Anne T. Taylor,Yixing Du,Ally M. Guiher,Merna Philip,Elizabeth Gerviacio Camacho,Devin Mediratta,Kelsey A Collins,K. De Boni,Silvana A. Garcia,Rajesh Kumar,Aiden N. Drake,Ahlam Hegazi,Lindsey Trank,Emily Benson,Grahame J. Kidd,David Terman,Ming Zhou +20 more
TL;DR: In this paper , the authors trace and 3D reconstruct three neighboring astrocytes using serial block-face scanning electron microscopy and reveal a spongiform morphology resulting from the abundance of reflexive and leaflet processes.
Journal ArticleDOI
miR-132 couples the circadian clock to daily rhythms of neuronal plasticity and cognition.
Sydney Aten,Katelin F. Hansen,Kaitlin H. Snider,Kelin L. Wheaton,Anisha Kalidindi,Ashley Garcia,Diego Alzate-Correa,Kari R. Hoyt,Karl Obrietan +8 more
TL;DR: It is shown that hippocampal miR-132 expression is gated by the time-of-day, with peak levels occurring during the circadian night, which raises the prospect that mi R-132 serves as a key route through which the circadian timing system imparts a daily rhythm on cognitive capacity.