S
Sylvie Jorieux
Researcher at Washington University in St. Louis
Publications - 60
Citations - 3177
Sylvie Jorieux is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Von Willebrand factor & Von Willebrand disease. The author has an hindex of 26, co-authored 60 publications receiving 2917 citations.
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Journal ArticleDOI
Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
Pierre Bruhns,Pierre Bruhns,Bruno Iannascoli,Bruno Iannascoli,Patrick England,Patrick England,David A. Mancardi,David A. Mancardi,Nadine Fernandez,Sylvie Jorieux,Marc Daëron,Marc Daëron +11 more
TL;DR: The results document how hFcgammaR specificity and affinity may account for the biological activities of antibodies and highlight the role of specific hF cgammaRs in the therapeutic and pathogenic effects of antibodies in disease.
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A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction.
TL;DR: Results support the concept that the bleeding diathesis of this patient appears to be due mainly to her abnormal vWF preventing FVIII/vWF interaction, which could be considered as a new variant of vWD.
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Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0
Béatrice Teylaert,Edwige Meurice,Marie Bobowski,Marie Bobowski,Anne Harduin-Lepers,Anne Harduin-Lepers,Christine Gaucher,Alexandre Fontayne,Sylvie Jorieux,Philippe Delannoy,Philippe Delannoy +10 more
TL;DR: Cloned and characterized the rat fut8 gene and several consensus sequences for potential transcriptional repressors are evidenced that will be useful to better control the fucosylation of recombinant mAbs produced in these cells.
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Chronic lymphocytic leukaemia cells are efficiently killed by an anti‐CD20 monoclonal antibody selected for improved engagement of FcγRIIIA/CD16
Christophe De Romeuf,Charles-Antoine Dutertre,Magali Le Garff-Tavernier,Magali Le Garff-Tavernier,Nathalie Fournier,Christine Gaucher,Arnaud Glacet,Sylvie Jorieux,Nicolas Bihoreau,Christian Behrens,Roland Beliard,Vincent Vieillard,Vincent Vieillard,Bruno Cazin,Dominique Bourel,J F Prost,Jean-Luc Teillaud,Hélène Merle-Béral +17 more
TL;DR: EMAB‐6 mAb represents a promising drug candidate for the treatment of CLL by inducing a strong cytotoxicity against tumour cells that express low CD20 levels.
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Gene Defects in 150 Unrelated French Cases with Type 2 von Willebrand Disease: from the Patient to the Gene
Dominique Meyer,Edith Fressinaud,Christine Gaucher,Jean-Maurice Lavergne,Lysiane Hilbert,Anne-Sophie Ribba,Sylvie Jorieux,Claudine Mazurier +7 more
TL;DR: This study of a large number of French variants of vWD brings further insight into the relationship between phenotype and genotype as well as finding new candidate mutations in the A1 domain.