Journal ArticleDOI
Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
Pierre Bruhns,Pierre Bruhns,Bruno Iannascoli,Bruno Iannascoli,Patrick England,Patrick England,David A. Mancardi,David A. Mancardi,Nadine Fernandez,Sylvie Jorieux,Marc Daëron,Marc Daëron +11 more
Reads0
Chats0
TLDR
The results document how hFcgammaR specificity and affinity may account for the biological activities of antibodies and highlight the role of specific hF cgammaRs in the therapeutic and pathogenic effects of antibodies in disease.About:
This article is published in Blood.The article was published on 2009-04-16. It has received 1273 citations till now. The article focuses on the topics: Fc-Gamma Receptor & Immunoglobulin G.read more
Citations
More filters
Journal ArticleDOI
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
TL;DR: The current state of understanding of T-cell costimulatory mechanisms and checkpoint blockade, primarily of CTLA4 and PD-1, is reviewed, and conceptual gaps in knowledge are highlighted.
Journal ArticleDOI
IgG subclasses and allotypes: from structure to effector functions.
TL;DR: IgG-polymorphisms and post-translational modification of the antibodies in the form of glycosylation, affect IgG-function will be the focus of the current review.
Journal ArticleDOI
Therapeutic antibodies for autoimmunity and inflammation
Andrew C. Chan,Paul Carter +1 more
TL;DR: How key insights obtained from the development of therapeutic antibodies complemented by newer antibody engineering technologies are delivering a second generation of therapeutic antibody with promise for greater clinical efficacy and safety is reviewed.
Journal ArticleDOI
Strategies and challenges for the next generation of therapeutic antibodies
TL;DR: Strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions are discussed.
Journal ArticleDOI
Properties of mouse and human IgG receptors and their contribution to disease models
TL;DR: These studies led to the identification of specific cell populations responsible for the induction of various inflammatory diseases and have revealed, in particular, the unexpected contribution of neutrophils and monocytes to the induction of anaphylactic shock.
References
More filters
Journal ArticleDOI
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
Guillaume Cartron,Laurent Dacheux,Gilles Salles,Philippe Solal-Celigny,Pierre Bardos,Philippe Colombat,Hervé Watier +6 more
TL;DR: This study showed an association between the FCGR3A genotype and clinical and molecular responses to rituximab, and will certainly give rise to new pharmacogenetic approaches to the management of patients with non-Hodgkin lymphomas.
Journal ArticleDOI
The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity.
Toyohide Shinkawa,Kazuyasu Nakamura,Naoko Yamane,Emi Shoji-Hosaka,Yutaka Kanda,Mikiko Sakurada,Kazuhisa Uchida,Hideharu Anazawa,Mitsuo Satoh,Motoo Yamasaki,Nobuo Hanai,Kenya Shitara +11 more
TL;DR: The results indicate that the lack of fucosylation of IgG1 has the most critical role in enhancement of ADCC, although several reports have suggested the importance of Gal or bisecting GlcNAc and provide important information to produce the effective therapeutic antibody.
Journal ArticleDOI
Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma
Wen-Kai Weng,Ronald Levy +1 more
TL;DR: Data support the hypothesis that ADCC plays an important role in the clinical effect of rituximab at the level of the effector cell.
Journal ArticleDOI
Fc RECEPTOR BIOLOGY
TL;DR: In this paper, a review of membrane Fc receptors (FcR) of the immunoglobulin superfamily is presented, focusing on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed.