T
Tadahiko Hazato
Researcher at Institute of Medical Science
Publications - 44
Citations - 904
Tadahiko Hazato is an academic researcher from Institute of Medical Science. The author has contributed to research in topics: Aminopeptidase & Spinorphin. The author has an hindex of 18, co-authored 44 publications receiving 866 citations.
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Journal ArticleDOI
Bovine lactoferrin inhibits tumor-induced angiogenesis
Mariko Shimamura,Yukio Yamamoto,Hiromi Ashino,Tsutomu Oikawa,Tadahiko Hazato,Hiroyuki Tsuda,Masaaki Iigo +6 more
TL;DR: It is suggested that bLF participates as a regulator of angiogenesis, possibly explained by blocking endothelial function and inducing IL‐18 production, which may contribute to antitumor activity.
Journal ArticleDOI
Inhibition of angiogenesis by humulone, a bitter acid from beer hop.
Mariko Shimamura,Tadahiko Hazato,Hiromi Ashino,Yukio Yamamoto,Eri Iwasaki,Hiroyasu Tobe,Kei Yamamoto,Shozo Yamamoto +7 more
TL;DR: Humulone is a potentAngiogenic inhibitor, and may be a novel powerful tool for the therapy of various angiogenic diseases involving solid tumor growth and metastasis.
Journal ArticleDOI
Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII
TL;DR: Results indicated that tynorphin had a more effective structure for expression of inhibitory activity toward DPPIII, suggesting that tyNorphin is a specific inhibitor of DPP III.
Journal ArticleDOI
Isolation of angiotensin-converting enzyme inhibitor from porcine plasma
Tadahiko Hazato,Ryoichi Kase +1 more
TL;DR: An inhibitory peptide of angiotensin-converting enzyme was purified from porcine plasma and the amino acid sequence of the inhibitor was determined as leucyl-valyl-leucine by Edman procedure, supported by mass spectrometric analysis.