T
Tadanori Mammoto
Researcher at Medical College of Wisconsin
Publications - 118
Citations - 11869
Tadanori Mammoto is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Angiogenesis & Extracellular matrix. The author has an hindex of 40, co-authored 110 publications receiving 10390 citations. Previous affiliations of Tadanori Mammoto include Beth Israel Deaconess Medical Center & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
Netanel Korin,Mathumai Kanapathipillai,Benjamin D. Matthews,Marilena Crescente,Marilena Crescente,Alexander Brill,Alexander Brill,Tadanori Mammoto,Kaustabh Ghosh,Samuel Jurek,Sidi A. Bencherif,Sidi A. Bencherif,Deen Bhatta,Ahmet U. Coskun,Charles L. Feldman,Denisa D. Wagner,Denisa D. Wagner,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +19 more
TL;DR: A biomimetic strategy that uses high shear stress caused by vascular narrowing as a targeting mechanism—in the same way platelets do—to deliver drugs to obstructed blood vessels offers a potential new approach for treatment of life-threatening diseases that result from acute vascular occlusion.
Journal ArticleDOI
Paper-supported 3D cell culture for tissue-based bioassays
Ratmir Derda,Anna Laromaine,Akiko Mammoto,Sindy K. Y. Tang,Tadanori Mammoto,Donald E. Ingber,George M. Whitesides +6 more
TL;DR: It is reported that stacking and destacking layers of paper impregnated with suspensions of cells in extracellular matrix hydrogel makes it possible to control oxygen and nutrient gradients in 3D and to analyze molecular and genetic responses.
Journal ArticleDOI
Mechanosensitive mechanisms in transcriptional regulation.
TL;DR: How the mechanical control of gene transcription contributes to the maintenance of pluripotency, determination of cell fate, pattern formation and organogenesis, as well as how it is involved in the control of cell and tissue function throughout embryogenesis and adult life is reviewed.
Journal ArticleDOI
Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro
Yu Suke Torisawa,Catherine S. Spina,Tadanori Mammoto,Akiko Mammoto,James C. Weaver,Tracy Tat,James J. Collins,Donald E. Ingber +7 more
TL;DR: A method for fabricating 'bone marrow–on–a–chip' that permits culture of living marrow with a functional hematopoietic niche in vitro by first engineering new bone in vivo, removing it whole and perfusing it with culture medium in a microfluidic device is described.
Journal ArticleDOI
Mechanobiology and developmental control.
TL;DR: Work that has revealed the central role that physical forces and extracellular matrix mechanics play in the control of cell fate switching, pattern formation, and tissue development in the embryo is reviewed and how these same mechanical signals contribute to tissue homeostasis and developmental control throughout adult life is reviewed.