T
Takaaki Ohtake
Researcher at University of California, San Diego
Publications - 6
Citations - 2776
Takaaki Ohtake is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cathelicidin & Innate immune system. The author has an hindex of 6, co-authored 6 publications receiving 2672 citations. Previous affiliations of Takaaki Ohtake include Veterans Health Administration.
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Journal ArticleDOI
Innate antimicrobial peptide protects the skin from invasive bacterial infection.
Victor Nizet,Takaaki Ohtake,Takaaki Ohtake,Xavier Lauth,Xavier Lauth,Janet M. Trowbridge,Janet M. Trowbridge,Jennifer A. Rudisill,Jennifer A. Rudisill,Robert A. Dorschner,Robert A. Dorschner,Vasumati K. Pestonjamasp,Vasumati K. Pestonjamasp,Joseph Piraino,Kenneth H. Huttner,Richard L. Gallo,Richard L. Gallo +16 more
TL;DR: It is shown that cathelicidins are an important native component of innate host defence in mice and provide protection against necrotic skin infection caused by Group A Streptococcus (GAS).
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Cutaneous Injury Induces the Release of Cathelicidin Anti-Microbial Peptides Active Against Group A Streptococcus
Robert A. Dorschner,Vasumati K. Pestonjamasp,Seema Tamakuwala,Takaaki Ohtake,Jennifer A. Rudisill,Victor Nizet,Birgitta Agerberth,Gudmunder H. Gudmundsson,Richard L. Gallo +8 more
TL;DR: Cathelicidins are well suited to provide defense against infections due to group A Streptococcus, and represent an important element of cutaneous innate immunity.
Journal ArticleDOI
Biology and clinical relevance of naturally occurring antimicrobial peptides.
TL;DR: Current and future studies are likely to implicate the presence of antimicrobial peptides in several unexplained human inflammatory disorders and to provide novel therapeutic approaches to the treatment of disease.
Journal ArticleDOI
Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin.
Masamoto Murakami,Takaaki Ohtake,Robert A. Dorschner,Richard L. Gallo,Birgit Schittek,Claus Garbe +5 more
TL;DR: Results indicate that cathelicidin is secreted in human sweat, has potent anti-microbial activity against both gram-positive and gram-negative bacteria, and can, after processing from the preproform, provide a barrier for protection against infection.
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Cathelicidin Antimicrobial Peptides are Expressed in Salivary Glands and Saliva
TL;DR: Results indicate that cathelicidins are present in the salivary system, in some oral epithelia, and in saliva, contributing to broad-spectrum defense of the oral cavity.