B
Birgit Schittek
Researcher at University of Tübingen
Publications - 116
Citations - 8225
Birgit Schittek is an academic researcher from University of Tübingen. The author has contributed to research in topics: Melanoma & Staphylococcus aureus. The author has an hindex of 48, co-authored 108 publications receiving 7366 citations. Previous affiliations of Birgit Schittek include University of Cologne.
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Journal ArticleDOI
Dermcidin: a novel human antibiotic peptide secreted by sweat glands.
Birgit Schittek,Rainer Hipfel,Birgit Sauer,Jürgen Bauer,Hubert Kalbacher,Stefan Stevanovic,Markus Schirle,Kristina Schroeder,Nikolaus Blin,Friedegund Meier,Gernot Rassner,Claus Garbe +11 more
TL;DR: In sweat, a proteolytically processed 47–amino acid peptide was generated that showed antimicrobial activity in response to a variety of pathogenic microorganisms, indicating that sweat plays a role in the regulation of human skin flora through the presence of an antimicrobial peptide.
Journal ArticleDOI
Human commensals producing a novel antibiotic impair pathogen colonization
Alexander Zipperer,Martin C. Konnerth,Claudia Laux,Anne Berscheid,Daniela Janek,Daniela Janek,Christopher Weidenmaier,Marc Burian,Nadine A. Schilling,Christoph Slavetinsky,Matthias Marschal,Matthias Willmann,Hubert Kalbacher,Birgit Schittek,Heike Brötz-Oesterhelt,Stephanie Grond,Andreas Peschel,Bernhard Krismer +17 more
TL;DR: It is shown that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by S. aureus, and a rare example of a non-ribosomally synthesized bioactive compound from human-associated bacteria.
Journal ArticleDOI
Maintenance of B-cell memory by long-lived cells generated from proliferating precursors
Birgit Schittek,Klaus Rajewsky +1 more
TL;DR: It is shown that after an initial phase of extensive proliferation after primary immunization, memory cells can persist in the organism for extended periods of time in the absence of cell division.
Journal ArticleDOI
Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin.
Masamoto Murakami,Takaaki Ohtake,Robert A. Dorschner,Richard L. Gallo,Birgit Schittek,Claus Garbe +5 more
TL;DR: Results indicate that cathelicidin is secreted in human sweat, has potent anti-microbial activity against both gram-positive and gram-negative bacteria, and can, after processing from the preproform, provide a barrier for protection against infection.
Journal ArticleDOI
Metastatic pathways and time courses in the orderly progression of cutaneous melanoma.
Friedegund Meier,S. Will,U. Ellwanger,B. Schlagenhauff,Birgit Schittek,Gernot Rassner,Claus Garbe +6 more
TL;DR: A large number of patients who develop clinical metastases following treatment of a primary cutaneous melanoma initial present with locoregional metastases and one‐third initially present with distant metastases.