T
Takahiro Kamada
Researcher at Nagoya University
Publications - 6
Citations - 1098
Takahiro Kamada is an academic researcher from Nagoya University. The author has contributed to research in topics: Blockade & CD8. The author has an hindex of 4, co-authored 5 publications receiving 427 citations.
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Journal ArticleDOI
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
Takahiro Kamada,Yosuke Togashi,Christopher Tay,Danbee Ha,Akinori Sasaki,Yoshiaki Nakamura,Eiichi Sato,Shota Fukuoka,Yasuko Tada,Atsushi Tanaka,Hiromasa Morikawa,Akihito Kawazoe,Takahiro Kinoshita,Kohei Shitara,Shimon Sakaguchi,Hiroyoshi Nishikawa +15 more
TL;DR: PD-1 blockade may facilitate the proliferation of highly suppressive PD-1+ eTreg cells in HPDs, resulting in inhibition of antitumor immunity andletion of the former may help treat and prevent HPD.
Journal ArticleDOI
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.
Shogo Kumagai,Yosuke Togashi,Takahiro Kamada,Eri Sugiyama,Hitomi Nishinakamura,Yoshiko Takeuchi,Kochin Vitaly,Kota Itahashi,Yuka Maeda,Shigeyuki Matsui,Takuma Shibahara,Yamashita Yasuho,Takuma Irie,Ayaka Tsuge,Shota Fukuoka,Akihito Kawazoe,Hibiki Udagawa,Keisuke Kirita,Keiju Aokage,Genichiro Ishii,Takeshi Kuwata,Kenta Nakama,Masahito Kawazu,Toshihide Ueno,Naoya Yamazaki,Koichi Goto,Masahiro Tsuboi,Hiroyuki Mano,Toshihiko Doi,Kohei Shitara,Hiroyoshi Nishikawa +30 more
TL;DR: A biomarker based on PD-1 positivity of effector and regulatory T cells in the tumor microenvironment that accurately predicts the effectiveness of checkpoint blockade in patients is developed.
Journal ArticleDOI
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.
Shogo Kumagai,Shohei Koyama,Kota Itahashi,Tokiyoshi Tanegashima,Yi-Tzu Lin,Yosuke Togashi,Takahiro Kamada,Takuma Irie,Genki Okumura,Hidetoshi Kono,Daisuke Ito,Rika Fujii,Sho Watanabe,Atsuo Sai,Shota Fukuoka,Eri Sugiyama,Gokuran Watanabe,Takuya Owari,Hitomi Nishinakamura,Daisuke Sugiyama,Yuka Maeda,Akihito Kawazoe,Hiroki Yukami,Keigo Chida,Yuuki Ohara,Tatsuya Yoshida,Yuki Shinno,Yuki Takeyasu,Masayuki Shirasawa,Kenta Nakama,Keiju Aokage,Jun Suzuki,Genichiro Ishii,Takeshi Kuwata,Naoya Sakamoto,Masahito Kawazu,Toshihide Ueno,Taisuke Mori,Naoya Yamazaki,Masahiro Tsuboi,Yasushi Yatabe,Takahiro Kinoshita,Toshihiko Doi,Kohei Shitara,Hiroyuki Mano,Hiroyoshi Nishikawa +45 more
TL;DR: In this paper , the balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 blockade therapy through the competition of their reactivation.
Journal ArticleDOI
Association of gut microbiome with immune status and clinical response in solid tumor patients who received on anti-PD-1 therapies.
Shota Fukuoka,Motooka Daisuke,Yosuke Togashi,Eri Sugiyama,Hibiki Udagawa,Keisuke Kirita,Takahiro Kamada,Akihito Kawazoe,Koichi Goto,Toshihiko Doi,Kohei Shitara,Shota Nakamura,Hiroyoshi Nishikawa +12 more
TL;DR: This data indicates that once the immune check point blockade in patients with various tumor types finally experienced disease progression, the likelihood of disease progression is higher in patients treated with ICB than with placebo.
Journal ArticleDOI
Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens.
Yukie Kashima,Yosuke Togashi,Shota Fukuoka,Takahiro Kamada,Takuma Irie,Ayako Suzuki,Yoshiaki Nakamura,Kohei Shitara,Tatsunori Minamide,Taku Yoshida,Naofumi Taoka,Tatsuya Kawase,Teiji Wada,Koichiro Inaki,Masataka Chihara,Yukihiko Ebisuno,Sakiyo Tsukamoto,Ryo Fujii,Akihiro Ohashi,Yutaka Suzuki,Katsuya Tsuchihara,Hiroyoshi Nishikawa,Toshihiko Doi +22 more
TL;DR: Wang et al. as mentioned in this paper investigated immune profiles using the single-cell analyses of endoscopically- or surgically-resected tumors, and peripheral blood mononuclear cells from gastric cancer patients.