Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.
Shogo Kumagai,Shohei Koyama,Kota Itahashi,Tokiyoshi Tanegashima,Yi-Tzu Lin,Yosuke Togashi,Takahiro Kamada,Takuma Irie,Genki Okumura,Hidetoshi Kono,Daisuke Ito,Rika Fujii,Sho Watanabe,Atsuo Sai,Shota Fukuoka,Eri Sugiyama,Gokuran Watanabe,Takuya Owari,Hitomi Nishinakamura,Daisuke Sugiyama,Yuka Maeda,Akihito Kawazoe,Hiroki Yukami,Keigo Chida,Yuuki Ohara,Tatsuya Yoshida,Yuki Shinno,Yuki Takeyasu,Masayuki Shirasawa,Kenta Nakama,Keiju Aokage,Jun Suzuki,Genichiro Ishii,Takeshi Kuwata,Naoya Sakamoto,Masahito Kawazu,Toshihide Ueno,Taisuke Mori,Naoya Yamazaki,Masahiro Tsuboi,Yasushi Yatabe,Takahiro Kinoshita,Toshihiko Doi,Kohei Shitara,Hiroyuki Mano,Hiroyoshi Nishikawa +45 more
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TLDR
In this paper , the balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 blockade therapy through the competition of their reactivation.About:
This article is published in Cancer Cell.The article was published on 2022-01-01 and is currently open access. It has received 160 citations till now. The article focuses on the topics: Medicine & Effector.read more
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Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
TL;DR: In this paper , the effect of lactate on cancer and immune cells can be highly complex and hard to decipher, which is further confounded by acidic protons, a co-product of glycolysis.
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The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment
Seong Keun Kim,Sun Wook Cho +1 more
TL;DR: The effects of the TME on cancer cells and immune cells, especially how cancer cells evade the immune system, are examined, and anti-cancer strategies based on TME are examined.
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'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives.
TL;DR: In this paper , the Warburg effect via CRISPR-Cas9 disruption of glucose-6-phosphate isomerase (GPI-KO) or lactate dehydrogenases (LDHA/B-DKO) is revisited.
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Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity
TL;DR: In this article , the authors discuss the common and distinct metabolic profiles of regulatory T cells in peripheral tissues and the TME, as well as the differences between Tregs and other conventional T cells.
Journal ArticleDOI
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
TL;DR: Wang et al. as discussed by the authors discussed the existing obstacles and future perspectives in the development of antitumor immunotherapy, and illustrated several formation mechanisms of immunosuppressive tumor microenvironment.
References
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TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
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