H
Hitomi Nishinakamura
Researcher at Kyushu University
Publications - 8
Citations - 1172
Hitomi Nishinakamura is an academic researcher from Kyushu University. The author has contributed to research in topics: Cytokine & Signal transduction. The author has an hindex of 6, co-authored 7 publications receiving 945 citations.
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Journal ArticleDOI
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
Hiroyuki Mori,Reiko Hanada,Toshikatsu Hanada,Daisuke Aki,Ryuichi Mashima,Hitomi Nishinakamura,Takehiro Torisu,Kenneth R. Chien,Hideo Yasukawa,Akihiko Yoshimura +9 more
TL;DR: In this article, the suppressor of cytokine signaling-3 (Socs3) is shown to be a negative feedback regulator of leptin signaling involved in leptin resistance, and the negative regulatory role of Socs3 in leptin signaling in vivo is demonstrated.
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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.
Shogo Kumagai,Shohei Koyama,Kota Itahashi,Tokiyoshi Tanegashima,Yi-Tzu Lin,Yosuke Togashi,Takahiro Kamada,Takuma Irie,Genki Okumura,Hidetoshi Kono,Daisuke Ito,Rika Fujii,Sho Watanabe,Atsuo Sai,Shota Fukuoka,Eri Sugiyama,Gokuran Watanabe,Takuya Owari,Hitomi Nishinakamura,Daisuke Sugiyama,Yuka Maeda,Akihito Kawazoe,Hiroki Yukami,Keigo Chida,Yuuki Ohara,Tatsuya Yoshida,Yuki Shinno,Yuki Takeyasu,Masayuki Shirasawa,Kenta Nakama,Keiju Aokage,Jun Suzuki,Genichiro Ishii,Takeshi Kuwata,Naoya Sakamoto,Masahito Kawazu,Toshihide Ueno,Taisuke Mori,Naoya Yamazaki,Masahiro Tsuboi,Yasushi Yatabe,Takahiro Kinoshita,Toshihiko Doi,Kohei Shitara,Hiroyuki Mano,Hiroyoshi Nishikawa +45 more
TL;DR: In this paper , the balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 blockade therapy through the competition of their reactivation.
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Negative regulation of cytokine signaling and immune responses by SOCS proteins.
TL;DR: This review focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.
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Induction of Hyper Th1 Cell-Type Immune Responses by Dendritic Cells Lacking the Suppressor of Cytokine Signaling-1 Gene
Toshikatsu Hanada,Kentaro Tanaka,Yumiko Matsumura,Moriyasu Yamauchi,Hitomi Nishinakamura,Hiroyuki Aburatani,Ryuichi Mashima,Masato Kubo,Takashi Kobayashi,Akihiko Yoshimura +9 more
TL;DR: It is demonstrated that SOCS1-deficient DCs induce stronger Th1-type responses both in vitro and in vivo, and proposed that reduction of the SOCS 1 gene expression in DCs leads to CD8α+ DC-like phenotype which promotes Th 1-type hyperresponses.
Journal ArticleDOI
The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.
Kanta Miyoshi,Kanta Miyoshi,Toru Wakioka,Hitomi Nishinakamura,Masaki Kamio,Lu Yang,Makoto Inoue,Mamoru Hasegawa,Yoshikazu Yonemitsu,Setsuro Komiya,Akihiko Yoshimura +10 more
TL;DR: It is demonstrated that Spred1 inhibits the metastasis of LM8 cells in nude mice and suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.