Hidetoshi Kono

TL;DR: It is demonstrated that the structural data can be used to predict DNA target sequences for regulatory proteins, and the results show that target binding sites for several regulatory proteins are successfully predicted, suggest that this method can serve as a powerful tool for predicting multiple target sites and target genes for Regulatory proteins.

TL;DR: The dome-like behaviour around EG∼0 combined with the transport, thermodynamic and optical results are fully consistent with an excitonic insulator phase in Ta2NiSe5, and the entropy associated with the transition being consistent with a primarily electronic origin.

TL;DR: It is shown how the patterns of interaction, either observed in known structures or derived from computer simulations, confer recognition specificity, and how they can be used to examine the relationship between structure and specificity and to predict target DNA sequences used by regulatory proteins.

TL;DR: In this paper , the balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 blockade therapy through the competition of their reactivation.

TL;DR: The first release of the Thermodynamic Database for Proteins and Mutants (ProTherm) contains more than 3300 data of several thermodynamic parameters for wild type and mutant proteins, which are important for understanding the mechanism of protein stability.