T
Takao Hirai
Researcher at Aichi Gakuin University
Publications - 39
Citations - 627
Takao Hirai is an academic researcher from Aichi Gakuin University. The author has contributed to research in topics: Osteoblast & Osteoclast. The author has an hindex of 13, co-authored 38 publications receiving 512 citations. Previous affiliations of Takao Hirai include Fukuyama University & Harvard University.
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Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life
TL;DR: It is found that inactivation of the PPR in chondrocytes postnatally leads to accelerated differentiation of chondROcytes, followed by disappearance of the growth plate, which suggests that the major consequences of PPR activation are similar in both the fetal and postnatal growth plates.
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Contribution of the peripheral 5-HT2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain
TL;DR: It is proposed that the 5-HT 2A receptor in the hyperalgesic hind paw function as an agonist-independent active receptor following constriction of the sciatic nerve, and that sarpogrelate and ketanserin act as inverse agonists of this receptor and suppress its activation.
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G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.
Andrei S. Chagin,Karuna K Vuppalapati,Tatsuya Kobayashi,Jun Guo,Takao Hirai,Min Chen,Stefan Offermanns,Lee S. Weinstein,Henry M. Kronenberg +8 more
TL;DR: It is demonstrated that stem-like chondrocytes undergo apoptosis in the absence of the receptor (PPR) for parathyroid hormone-related protein, and G(s)α is the major mediator of the anti-differentiation action of the PPR.
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β-adrenergic receptor signaling regulates Ptgs2 by driving circadian gene expression in osteoblasts
TL;DR: It is suggested that Iso-mediated induction of Nfil3 in osteoblasts regulates the expression of Ptgs2 by driving theexpression of circadian clock genes.
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α1-adrenergic receptor signaling in osteoblasts regulates clock genes and bone morphogenetic protein 4 expression through up-regulation of the transcriptional factor nuclear factor IL-3 (Nfil3)/E4 promoter-binding protein 4 (E4BP4).
TL;DR: The stimulation of phenylephrine (PHE), a nonspecific α1-AR agonist, increased the transcriptional factor Nfil3/E4BP4 and led to the rhythmic expression of bone morphogenetic protein 4 (Bmp4) in MC3T3-E1 osteoblastic cells, which suggested that N Fil3 repressed the expression of the Bmp4 gene during a circadian cycle.