T
Takao Naganuma
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 7
Citations - 1332
Takao Naganuma is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Paraspeckle & Paraspeckles. The author has an hindex of 7, co-authored 7 publications receiving 1116 citations. Previous affiliations of Takao Naganuma include University of Tsukuba.
Papers
More filters
Journal ArticleDOI
NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
Tetsuro Hirose,Giorgio Virnicchi,Akie Tanigawa,Takao Naganuma,Ruohan Li,Hiroshi Kimura,Takahide Yokoi,Shinichi Nakagawa,Marianne Bénard,Archa H. Fox,Gérard Pierron +10 more
TL;DR: Paraspeckles are subnuclear structures formed around NEAT1 lncRNA that affect the transcription of several genes, arguing for a novel role for lnc RNA in gene regulation.
Journal ArticleDOI
Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles.
Takao Naganuma,Shinichi Nakagawa,Akie Tanigawa,Yasnory F. Sasaki,Naoki Goshima,Tetsuro Hirose +5 more
TL;DR: In vitro binding assays showed that HNRNPK competed with CPSF6 for binding to NUDT21, which was the underlying mechanism to arrest CFIm binding by HNR NPK, which led to the preferential accumulation of NEAT1_2 and initiated paraspeckle construction with multiple PSPs.
Journal ArticleDOI
Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice.
TL;DR: Mouse NEAT1 is required for paraspeckle formation in a subset of cells but is not essential for animal health and viability.
Journal ArticleDOI
Paraspeckle formation during the biogenesis of long non-coding RNAs.
Takao Naganuma,Tetsuro Hirose +1 more
TL;DR: NEAT1 expression is likely regulated at transcriptional and post-transcriptional steps under certain stress conditions, suggesting roles for paraspeckles in the lncRNA-mediated regulation of gene expression, such as the nucleocytoplasmic transport of mRNA in response to certain stimuli.
Journal ArticleDOI
SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies
Tetsuya Kawaguchi,Akie Tanigawa,Takao Naganuma,Yasuyuki Ohkawa,Sylvie Souquere,Gérard Pierron,Tetsuro Hirose +6 more
TL;DR: It is demonstrated that SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodeling complexes play an essential role in organizing the protein–protein interaction network of paraspeckles in a manner that does not require their canonical remodeling activity, suggesting the presence of a common pathway for the assembly of lncRNA-dependent nuclear bodies in mammalian cells.