S
Sylvie Souquere
Researcher at Institut Gustave Roussy
Publications - 65
Citations - 4615
Sylvie Souquere is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Autophagy & Apoptosis. The author has an hindex of 29, co-authored 60 publications receiving 3645 citations. Previous affiliations of Sylvie Souquere include Université Paris-Saclay & University of Paris-Sud.
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Journal ArticleDOI
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons
Arnaud Hubstenberger,Arnaud Hubstenberger,Maïté Courel,Marianne Bénard,Sylvie Souquere,Michèle Ernoult-Lange,Racha Chouaib,Zhou Yi,Jean-Baptiste Morlot,Annie Munier,Magali Fradet,Maëlle Daunesse,Edouard Bertrand,Gérard Pierron,Julien Mozziconacci,Michel Kress,Dominique Weil +16 more
TL;DR: It is uncovered how P-bodies, by condensing and segregating repressed mRNAs, provide a physical substrate for the coordinated regulation of posttranscriptional mRNA regulons.
Journal ArticleDOI
Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation.
Tomohiro Yamazaki,Sylvie Souquere,Takeshi Chujo,Simon Kobelke,Yee Seng Chong,Archa H. Fox,Charles S. Bond,Shinichi Nakagawa,Gérard Pierron,Tetsuro Hirose +9 more
TL;DR: It is demonstrated that the enrichment of NONO dimers on the redundant NEAT1_2 subdomains initiates construction of phase-separated paraspeckles, providing mechanistic insights into lncRNA-based nuclear body formation.
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Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells.
Jihène Klibi,Toshiro Niki,Alexander Riedel,Catherine Pioche-Durieu,Sylvie Souquere,Eric Rubinstein,Sylvestre Le Moulec,Joël Guigay,Mitsuomi Hirashima,Fethi Guemira,Dinesh Adhikary,Josef Mautner,Philippe Busson +12 more
TL;DR: Results indicate that blocking galectin-9/Tim-3 interaction in vivo might alleviate the Th1-suppressive effect of NPC exosomes and sustain antitumoral T-cell responses and thereby improve clinical efficacy of immunotherapeutic approaches against NPC.
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Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.
Shensi Shen,Mireia Niso-Santano,Mireia Niso-Santano,Mireia Niso-Santano,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Tetsuo Takehara,Shoaib Ahmad Malik,Shoaib Ahmad Malik,Shoaib Ahmad Malik,Hervé Minoux,Sylvie Souquere,Sylvie Souquere,Guillermo Mariño,Guillermo Mariño,Guillermo Mariño,Sylvie Lachkar,Sylvie Lachkar,Sylvie Lachkar,Laura Senovilla,Laura Senovilla,Laura Senovilla,Lorenzo Galluzzi,Lorenzo Galluzzi,Oliver Kepp,Oliver Kepp,Oliver Kepp,Gérard Pierron,Gérard Pierron,Maria Chiara Maiuri,Maria Chiara Maiuri,Maria Chiara Maiuri,Hayato Hikita,Romano T. Kroemer,Guido Kroemer +35 more
TL;DR: An unsuspected mechanism of autophagy control that involves STAT3 and PKR as interacting partners is unraveled, which facilitates autophagic induction.
Journal ArticleDOI
Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral Latent Membrane Protein 1 and the immunomodulatory protein galectin 9
Cécile Keryer-Bibens,Catherine Pioche-Durieu,Cécile Villemant,Sylvie Souquere,Nozomu Nishi,Mitsuomi Hirashima,Jaap M. Middeldorp,Philippe Busson +7 more
TL;DR: This study provides the proof of concept that NPC cells can release HLA class-II positive exosomes containing galectin 9 and/or LMP1 and confirms that the L MP1 molecule has intrinsic T-cell inhibitory activity.