L
Lingling Lu
Researcher at Meijo University
Publications - 11
Citations - 798
Lingling Lu is an academic researcher from Meijo University. The author has contributed to research in topics: Silibinin & Prefrontal cortex. The author has an hindex of 10, co-authored 11 publications receiving 732 citations. Previous affiliations of Lingling Lu include Shenyang Pharmaceutical University.
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Journal ArticleDOI
Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits
Minae Niwa,Atsushi Kamiya,Rina Murai,Rina Murai,Ken Ichiro Kubo,Aaron J. Gruber,Kenji Tomita,Lingling Lu,Shuta Tomisato,Hanna Jaaro-Peled,Saurav Seshadri,Hideki Hiyama,Beverly Huang,Kazuhisa Kohda,Yukihiro Noda,Patricio O'Donnell,Kazunori Nakajima,Akira Sawa,Toshitaka Nabeshima,Toshitaka Nabeshima +19 more
TL;DR: The potential to generate an animal model via in utero gene transfer is reported to address an important question of how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia.
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Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice
Ping Lu,Ping Lu,Takayoshi Mamiya,Lingling Lu,Lingling Lu,Akihiro Mouri,Li Bo Zou,Taku Nagai,Masayuki Hiramatsu,Takashi Ikejima,Toshitaka Nabeshima +10 more
TL;DR: The effect of silibinin on the memory impairment and accumulation of oxidative stress induced by Aβ25–35 in mice is examined.
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Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment
Ping Lu,Takayoshi Mamiya,Lingling Lu,Lingling Lu,Akihiro Mouri,Minae Niwa,Hyoung-Chun Kim,Li Bo Zou,Taku Nagai,Kiyofumi Yamada,Takashi Ikejima,Toshitaka Nabeshima +11 more
TL;DR: Silibinin dose-dependently ameliorated the impairment of recognition memory caused by METH treatment in mice and found a correlation between the recognition values and dopamine and serotonin contents of the prefrontal cortex and hippocampus.
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Silibinin Attenuates Amyloid β25–35 Peptide-Induced Memory Impairments: Implication of Inducible Nitric-Oxide Synthase and Tumor Necrosis Factor-α in Mice
Ping Lu,Takayoshi Mamiya,Lingling Lu,Lingling Lu,Akihiro Mouri,Minae Niwa,Masayuki Hiramatsu,Li Bo Zou,Taku Nagai,Takashi Ikejima,Toshitaka Nabeshima +10 more
TL;DR: It is found that silibinin significantly attenuated memory deficits caused by Aβ25–35 in the cued and contextual fear-conditioning test and may be a potential candidate for an AD medication.
Journal ArticleDOI
Xanthoceraside attenuates amyloid β peptide25–35-induced learning and memory impairments in mice
Ping Lu,Takayoshi Mamiya,Lingling Lu,Akihiro Mouri,Takashi Ikejima,Hyoung Chum Kim,Li Bo Zou,Toshitaka Nabeshima +7 more
TL;DR: It is suggested that xanthoceraside attenuates memory impairments through amelioration of oxidative stress and inflammatory responses induced by Aβ25–35 and is a potential candidate for an AD treatment.