Takashi Itoh

TL;DR: It is found that a novel G protein-coupled receptor, TGR5, is responsive to bile acids as a cell-surface receptor, and was abundantly expressed in monocytes/macrophages in human and rabbit.

TL;DR: It is found that intracerebroventricular administration of GALP increased the plasma LH level but did not change the levels of other hormones, and accumulation of c-Fos protein was dramatically increased in the nuclei of LHRH-positive cells in the MPA by icv GALp administration.

TL;DR: Results suggest that GALP is a novel orexigenic and anxiogenic peptide, as a ligand for galanin receptor subtype GalR2, and the effect of the intracerebroventricular administration of GALp induced food intakes.

TL;DR: In this paper, the authors applied the refolding process using the aggregation suppressor Larginine in the renaturation of neurotrophin-3, and obtained biologically active recombinant human neurotrophic protein from the inclusion bodies.

TL;DR: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick labeling (TUNEL) staining and immunohistochemical study for caspase-3 and heat shock protein 72 (HSP72) showed that NT-3 treatment decreased the number of cells with DNA fragmentation and caspases and HSP72 expressions.