T
Takashi Nishida
Researcher at Okayama University
Publications - 8
Citations - 1042
Takashi Nishida is an academic researcher from Okayama University. The author has contributed to research in topics: Growth factor & CTGF. The author has an hindex of 8, co-authored 8 publications receiving 996 citations. Previous affiliations of Takashi Nishida include Hamamatsu University School of Medicine.
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Journal ArticleDOI
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
Tohru Nakanishi,Takashi Nishida,Tsuyoshi Shimo,Kappei Kobayashi,Toshikazu Kubo,Takuya Tamatani,Katsunari Tezuka,Masaharu Takigawa +7 more
TL;DR: Investigating CTGF/Hcs24 function in the chondrocytic cell line HCS-2/8 and rabbit growth cartilage (RGC) cells found that it proliferated more rapidly and expressed more mRNA of aggrecan and type X collagen than the control cells.
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Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro.
TL;DR: Nakanishi et al. as discussed by the authors investigated the effects of CTGF/Hcs24 on the proliferation and differentiation of osteoblastic cell lines in vitro and revealed that CTGF is a novel, potent stimulator for the proliferation in addition to chondrocytes and endothelial cells.
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Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases
Seiji Kondo,Satoshi Kubota,Tsuyoshi Shimo,Takashi Nishida,Gen Yosimichi,Takanori Eguchi,Toshio Sugahara,Masaharu Takigawa +7 more
TL;DR: The findings suggest that hypoxia stimulates MDA231 cells to release CTGF as an angiogenic modulator, which initiates the invasive angiogenesis cascade by modulating the balance of extracellular matrix synthesis and degradation via MMPs secreted by endothelial cells in response to CTGF.
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CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen‐activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular‐signal regulated kinase (ERK)
Gen Yosimichi,Tohru Nakanishi,Takashi Nishida,Takako Hattori,Teruko Takano-Yamamoto,Masaharu Takigawa +5 more
TL;DR: It is suggested that ERK mediates the CTGF/Hcs24-induced proliferation of chondrocytes, and that p38 MAPK mediating the CT GF/HCS24- induced differentiation of chondocytes.
Journal ArticleDOI
CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes
Takashi Nishida,Satoshi Kubota,Tohru Nakanishi,Takuo Kuboki,Gen Yosimichi,Seiji Kondo,Masaharu Takigawa +6 more
TL;DR: The results indicate that CTGF/Hcs24 promotes the proliferation and differentiation of articular chondrocytes, but does not promote their hypertrophy or calcification, and suggest that it may be useful for the repair ofArticular cartilage.