T
Takashi Sato
Researcher at Shinshu University
Publications - 172
Citations - 3437
Takashi Sato is an academic researcher from Shinshu University. The author has contributed to research in topics: Medicine & CpG Oligodeoxynucleotide. The author has an hindex of 30, co-authored 155 publications receiving 2752 citations. Previous affiliations of Takashi Sato include National Institutes of Health & Yokohama City University Medical Center.
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CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases.
TL;DR: Ongoing clinical studies indicate that CpG ODN are safe and well-tolerated when administered as adjuvants to humans, and that they can support increased vaccine-specific immune responses.
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Tumor necrosis factor-alpha stimulates the biosynthesis of matrix metalloproteinases and plasminogen activator in cultured human chorionic cells.
TL;DR: The results suggested that TNF alpha may participate in destruction of collagen and other connective tissue matrix components of fetal membranes and in promotion of uterine contractility in preterm parturition with intraamniotic infection.
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Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblats
Takashi Sato,Akira Ito,Yo Mori +2 more
TL;DR: The results provide the first evidence that IL-6 participates in the catabolism of the extracellular matrix components by modulating the effects of IL-1 on MMPs and TIMP synthesis as well as its direct effects on the synthesis of TIMP by connective tissue cells.
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Tumor necrosis factor bifunctionally regulates matrix metalloproteinases and tissue inhibitor of metalloproteinases (TIMP) production by human fibroblasts
TL;DR: The results suggest that TNF modulates the extracellular matrix degradation in human fibroblasts bifunctionally by the suppression of TIMP production in addition to the acceleration of matrix metalloproteinases production.
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Three-dimensional lower extremity alignment assessment system: Application to evaluation of component position after total knee arthroplasty
TL;DR: The proposed 3D method can be reliably used to assess component alignment after TKA and was determined directly with reconstructions from computed tomography scans and indirectly with the proposed bone and component image fitting techniques.