T
Takashi Shimano
Researcher at Osaka University
Publications - 103
Citations - 1778
Takashi Shimano is an academic researcher from Osaka University. The author has contributed to research in topics: Cancer & Carcinoma. The author has an hindex of 21, co-authored 103 publications receiving 1736 citations.
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Journal Article
Activation of the β-Catenin Gene in Primary Hepatocellular Carcinomas by Somatic Alterations Involving Exon 3
Yasuo Miyoshi,Kyoko Iwao,Yutaka Nagasawa,Tomohiko Aihara,Yo Sasaki,Shingi Imaoka,Masaru Murata,Takashi Shimano,Yusuke Nakamura +8 more
TL;DR: The results suggested that accumulation of beta-catenin due to amino acid substitutions at potential serine/threonine phosphorylation residues or at their neighboring codons or interstitial deletions involving exon 3 could contribute to hepatocellular carcinogenesis.
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Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.
Takahiro Mori,Hiroki Nagase,Akira Horii,Yasuo Miyoshi,Shuichi Nakatsuru,Takahisa Aoki,Hirofumi Arakawa,Yusuke Nakamura,Takashi Shimano,Akio Yanagisawa,Yukitaka Ushio,Sadamu Takano,Michio Ogawa,Masato Nakamura,Masabumi Shibuya,Ryo Nishikawa,Masao Matsutani,Yasuhide Hayashi,Hitoshi Takahashi,Fusahiro Ikuta,Tetsuro Nishihira,Shozo Mori +21 more
TL;DR: The results suggest that the APC gene is associated with pathogenesis of one feature of TS, but that at least one other gene is responsible for the genesis of neuroepithelial tumors in the CNS.
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Immunohistochemical study of p53 expression in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma.
Yasuhito Kawasaki,Takushi Monden,Hideki Morimoto,Murotani M,Yasuo Miyoshi,Tetsuro Kobayashi,Takashi Shimano,Takesada Mori +7 more
TL;DR: The present study demonstrated the usefulness of microwave fixation to preserve p53 and the immunohistochemical detection of p53 in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma can provide valuable information about the mechanism of carcinogenesis in coloreCTal epithelium.
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Preoperative iron supplementation and intraoperative transfusion during colorectal cancer surgery.
Masaki Okuyama,Kimimasa Ikeda,Takashi Shibata,Yasuo Tsukahara,Masashi Kitada,Takashi Shimano +5 more
TL;DR: Iron supplementation for at least 2 weeks before colorectal cancer surgery increases Hb and Ht values in anemic patients, and reduces the need for intraoperative transfusion.
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Significance of p53 expression as a prognostic factor in oesophageal squamous cell carcinoma
K Shimaya,Hitoshi Shiozaki,Masatoshi Inoue,Hideaki Tahara,Takushi Monden,Takashi Shimano,Takesada Mori +6 more
TL;DR: The results indicate that the nuclear accumulation of p53 might be an independent prognostic factor in patients with oesophageal squamous cell carcinomas.