T
Takayuki Yamashita
Researcher at Gunma University
Publications - 43
Citations - 1404
Takayuki Yamashita is an academic researcher from Gunma University. The author has contributed to research in topics: Fanconi anemia & FANCA. The author has an hindex of 21, co-authored 43 publications receiving 1316 citations. Previous affiliations of Takayuki Yamashita include University of Tokyo & Tokai University.
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Journal ArticleDOI
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Masato Sasaki,Kohichi Kawahara,Miki Nishio,Koshi Mimori,Ryunosuke Kogo,Koichi Hamada,Bunsho Itoh,Jia Wang,Yukako Komatsu,Yong Ryoul Yang,Hiroki Hikasa,Yasuo Horie,Takayuki Yamashita,Takehiko Kamijo,Yanping Zhang,Yan Zhu,Carol Prives,Toru Nakano,Tak W. Mak,Takehiko Sasaki,Tomohiko Maehama,Masaki Mori,Masaki Mori,Akira Suzuki,Akira Suzuki +24 more
TL;DR: PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus and blocking Mdm2-mediated ubiquitination of p53.
Journal ArticleDOI
The fanconi anemia pathway requires faa phosphorylation and faa/fac nuclear accumulation
Takayuki Yamashita,Gary M. Kupfer,Dieter Naf,Ahmed Suliman,Hans Joenje,Shigetaka Asano,Alan D. D'Andrea +6 more
TL;DR: The results support the idea that multiple gene products cooperate in the FA Pathway and seem to define a signaling pathway required for the maintenance of genomic stability and normal hematopoiesis.
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Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants
Daiki Adachi,Tsukasa Oda,Hiroshi Yagasaki,Keiko Nakasato,Toshiyasu Taniguchi,Alan D. D'Andrea,Shigetaka Asano,Takayuki Yamashita +7 more
TL;DR: Reconstitution of the FA pathway by group II and III mutants closely correlated with cellular sensitivity to MMC, which may partly account for the phenotypic variation seen in FA patients.
Journal ArticleDOI
Parathyroid Hormone-Related Protein in Adult T-Cell Leukemia-Lymphoma
Toru Motokura,Seiji Fukumoto,Toshio Matsumoto,Shunji Takahashi,Akira Fujita,Takayuki Yamashita,Tetsuya Igarashi,Etsuro Ogata +7 more
TL;DR: RNA blot analysis showed that parathyroid hormone-related protein (PTHrP) messenger RNAs (mRNAs) were constitutively expressed in the tumor cells from all patients, which may be an important factor in the development of hypercalcemia in the patients with this disease.
Journal ArticleDOI
Clinical evaluation of calcium metabolism in adult T-cell leukemia/lymphoma.
Seiji Fukumoto,Toshio Matsumoto,Kyoji Ikeda,Takayuki Yamashita,Toshiki Watanabe,Kazunari Yamaguchi,Tetsuyuki Kiyokawa,Kiyoshi Takatsuki,Naohiko Shibuya,Etsuro Ogata +9 more
TL;DR: It is suggested that derangements in calcium metabolism develop by a similar mechanism in patients with ATLL and the importance of the measurement of urinary calcium excretion for early detection and prevention of fatal hypercalcemia in patientswith ATLL is indicated.