T
Toshiki Watanabe
Researcher at University of Tokyo
Publications - 281
Citations - 13100
Toshiki Watanabe is an academic researcher from University of Tokyo. The author has contributed to research in topics: T-cell leukemia & Leukemia. The author has an hindex of 57, co-authored 279 publications receiving 11726 citations. Previous affiliations of Toshiki Watanabe include St. Marianna University School of Medicine & Nagasaki University.
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Journal ArticleDOI
Integrated molecular analysis of adult T cell leukemia/lymphoma
Keisuke Kataoka,Yasunobu Nagata,Akira Kitanaka,Yuichi Shiraishi,Teppei Shimamura,Jun-ichirou Yasunaga,Yasushi Totoki,Kenichi Chiba,Aiko Sato-Otsubo,Genta Nagae,Ryohei Ishii,Satsuki Muto,Shinichi Kotani,Yosaku Watatani,June Takeda,Masashi Sanada,Hiroko Tanaka,Hiromichi Suzuki,Yusuke Sato,Yusuke Shiozawa,Tetsuichi Yoshizato,Kenichi Yoshida,Hideki Makishima,Masako Iwanaga,Guangyong Ma,Kisato Nosaka,Masakatsu Hishizawa,Hidehiro Itonaga,Yoshitaka Imaizumi,Wataru Munakata,Hideaki Ogasawara,Toshitaka Sato,Ken Sasai,Kenzo Muramoto,Marina Penova,Takahisa Kawaguchi,Hiromi Nakamura,Natsuko Hama,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Takuro Kameda,Tsuyoshi Nakamaki,Ken Ishiyama,Shuichi Miyawaki,Sung-Soo Yoon,Kensei Tobinai,Yasushi Miyazaki,Akifumi Takaori-Kondo,Fumihiko Matsuda,Kengo Takeuchi,Osamu Nureki,Hiroyuki Aburatani,Toshiki Watanabe,Tatsuhiro Shibata,Masao Matsuoka,Satoru Miyano,Kazuya Shimoda,Seishi Ogawa +58 more
TL;DR: The identified alterations overlap significantly with the HTLV-1 Tax interactome and are highly enriched for T cell receptor–NF-κB signaling, T cell trafficking and other T cell–related pathways as well as immunosurveillance.
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Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting
Kunihiro Tsukasaki,Olivier Hermine,Ali Bazarbachi,Lee Ratner,Juan Carlos Ramos,William J. Harrington,Deirdre O'Mahony,John Edward Janik,A Bittencourt,Graham P. Taylor,Kazunari Yamaguchi,Atae Utsunomiya,Kensei Tobinai,Toshiki Watanabe +13 more
TL;DR: A group of ATL researchers joined to form a consensus statement based on established data to define prognostic factors, clinical subclassifications, and treatment strategies, and a set of response criteria specific for ATL reflecting a combination of those for lymphoma and CLL was proposed.
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Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region
Takaomi Ishida,Seiichi Mizushima,Sakura Azuma,Norihiko Kobayashi,Tadashi Tojo,Kimie Suzuki,Shigemi Aizawa,Toshiki Watanabe,George Mosialos,Elliott Kieff,Tadashi Yamamoto,Jun-ichiro Inoue +11 more
TL;DR: Results suggest that TRAF6 could mediate the CD40 signal that is transduced by the amino-terminal domain (230-245) of theCD40 cytoplasmic region and appears to be independent of other known TRAF family proteins.
Journal ArticleDOI
TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
Takaomi Ishida,Tadashi Tojo,Tsutomu Aoki,Norihiko Kobayashi,Tsukasa Ohishi,Toshiki Watanabe,Tadashi Yamamoto,Jun-ichiro Inoue +7 more
TL;DR: The results suggest that TRAF5 and TRAF3 could be involved in both common and distinct signaling pathways emanating from CD40, which play crucial roles in B-cell function.
Journal ArticleDOI
Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-κB Pathway in Adult T Cell Leukemia and Other Cancers
Makoto Yamagishi,Kazumi Nakano,Ariko Miyake,Tadanori Yamochi,Yayoi Kagami,Akihisa Tsutsumi,Yuka Matsuda,Aiko Sato-Otsubo,Satsuki Muto,Atae Utsunomiya,Kazunari Yamaguchi,Kaoru Uchimaru,Seishi Ogawa,Toshiki Watanabe +13 more
TL;DR: A pathway involving Polycomb-mediated miRNA silencing and NF-κB activation is reported and a perspective involving the epigenetic program, inflammatory responses, and oncogenic signaling is provided.