T
Takehiko Yamanashi
Researcher at Tottori University
Publications - 32
Citations - 573
Takehiko Yamanashi is an academic researcher from Tottori University. The author has contributed to research in topics: Medicine & Delirium. The author has an hindex of 8, co-authored 18 publications receiving 376 citations. Previous affiliations of Takehiko Yamanashi include University of Iowa & Stanford University.
Papers
More filters
Journal ArticleDOI
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Masaaki Iwata,Kristie T. Ota,Xiaoyuan Li,Fumika Sakaue,Nanxin Li,Sophie Dutheil,Mounira Banasr,Vanja Duric,Vanja Duric,Takehiko Yamanashi,Koichi Kaneko,Kurt Rasmussen,Andrew L. Glasebrook,Anja Koester,Dekun Song,Kenneth A. Jones,Stevin H. Zorn,Gennady N. Smagin,Ronald S. Duman +18 more
TL;DR: These findings demonstrate that psychological "stress" is sensed by the innate immune system in the brain via the ATP/P2X7R-NLRP3 inflammasome cascade, and they identify novel therapeutic targets for the treatment of stress-related mood disorders and comorbid illnesses.
Journal ArticleDOI
Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses
Takehiko Yamanashi,Masaaki Iwata,Naho Kamiya,Kyohei Tsunetomi,Naofumi Kajitani,Nodoka Wada,Takahiro Iitsuka,Takahira Yamauchi,Akihiko Miura,Shenghong Pu,Yukihiko Shirayama,Ken Watanabe,Ronald S. Duman,Koichi Kaneko +13 more
TL;DR: It is demonstrated that Beta-hydroxybutyrate exerts antidepressant-like effects, possibly by inhibiting NLRP3-induced neuro-inflammation in the hippocampus, and that BHB may be a novel therapeutic candidate for the treatment of stress-related mood disorders.
Journal ArticleDOI
Relationship between hypothalamic-pituitary-adrenal axis dysregulation and insulin resistance in elderly patients with depression
Katsutoshi Yokoyama,Takeshi Yamada,Hideaki Mitani,Sayaka Yamada,Shenghong Pu,Takehiko Yamanashi,Hiroshi Matsumura,Kazuyuki Nakagome,Koichi Kaneko +8 more
TL;DR: This is the first study to directly demonstrate the relationship between HPA axis dysregulation assessed with the DEX/CRH test and the index of insulin resistance estimated as HOMA-R in elderly MDD patients.
Journal ArticleDOI
Prefrontal cortex infusion of beta‐hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant‐like effects in a rodent model of depression
Naofumi Kajitani,Masaaki Iwata,Akihiko Miura,Kyohei Tsunetomi,Takehiko Yamanashi,Ryoichi Matsuo,Tsuyoshi Nishiguchi,Saki Fukuda,Mayu Nagata,Midori Shibushita,Takahira Yamauchi,Shenghong Pu,Yukihiko Shirayama,Ken Watanabe,Koichi Kaneko +14 more
TL;DR: Beta‐hydroxybutyrate is administered directly into the brain in a rodent model of depression using a chronic unpredictable stress (CUS) paradigm to determine whether BHB specifically mediates actions in the brain.
Journal ArticleDOI
Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia
Shenghong Pu,Kazuyuki Nakagome,Takeshi Yamada,Masashi Itakura,Takehiko Yamanashi,Sayaka Yamada,Mieko Masai,Akihiko Miura,Takahira Yamauchi,Takahiro Satake,Masaaki Iwata,Izumi Nagata,David L. Roberts,Koichi Kaneko +13 more
TL;DR: The results suggest that ToM integrity is closely related to lateral PFC functional abnormalities found in patients with schizophrenia and provide evidence to suggest that NIRS could be used to identify biomarkers of social cognition function in subjects with schizophrenia.