S
Sophie Dutheil
Researcher at Yale University
Publications - 21
Citations - 1256
Sophie Dutheil is an academic researcher from Yale University. The author has contributed to research in topics: Neurogenesis & Vestibular system. The author has an hindex of 12, co-authored 19 publications receiving 934 citations. Previous affiliations of Sophie Dutheil include University of Provence & Erasmus University Rotterdam.
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Journal ArticleDOI
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Masaaki Iwata,Kristie T. Ota,Xiaoyuan Li,Fumika Sakaue,Nanxin Li,Sophie Dutheil,Mounira Banasr,Vanja Duric,Vanja Duric,Takehiko Yamanashi,Koichi Kaneko,Kurt Rasmussen,Andrew L. Glasebrook,Anja Koester,Dekun Song,Kenneth A. Jones,Stevin H. Zorn,Gennady N. Smagin,Ronald S. Duman +18 more
TL;DR: These findings demonstrate that psychological "stress" is sensed by the innate immune system in the brain via the ATP/P2X7R-NLRP3 inflammasome cascade, and they identify novel therapeutic targets for the treatment of stress-related mood disorders and comorbid illnesses.
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High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation
TL;DR: The results show that a high-fat diet (HFD; ~16 weeks) causes anxiety and anhedonic behaviors, and pharmacological blockade of the innate immune inflammasome system by repeated administration of an inhibitor of the purinergic P2X7 receptor blocks the anxiety caused by HFD.
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REDD1 is essential for stress-induced synaptic loss and depressive behavior
Kristie T. Ota,Rong-Jian Liu,Bhavya Voleti,Jaime G. Maldonado-Avilés,Vanja Duric,Masaaki Iwata,Sophie Dutheil,Catharine H. Duman,Steven Ray Boikess,David A. Lewis,Craig A. Stockmeier,Ralph J. DiLeone,Christopher S. Rex,George K. Aghajanian,Ronald S. Duman +14 more
TL;DR: Postmortem and preclinical findings identify REDD1 as a critical mediator of the atrophy of neurons and depressive behavior caused by chronic stress exposure.
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Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors.
Andrea Navarria,Eric S. Wohleb,Bhavya Voleti,Kristie T. Ota,Sophie Dutheil,Ashley E. Lepack,Jason M. Dwyer,Manabu Fuchikami,Astrid Becker,Filippo Drago,Ronald S. Duman +10 more
TL;DR: Findings indicate that mPFC is a critical mediator of the behavioral actions of scopolamine and identify the M1-AChR as a therapeutic target for the development of novel and selective rapid-acting antidepressants.
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Neurogenesis and astrogenesis contribution to recovery of vestibular functions in the adult cat following unilateral vestibular neurectomy: cellular and behavioral evidence.
TL;DR: It is concluded that the first 3 weeks after UVN represent a possible critical period in which important neuroplasticity mechanisms take place for promoting vestibular function recovery: reactive neurogenesis and astrogenesis might contribute highly to Vestibular compensation in the adult cat.