T
Takeshi Aoyama
Researcher at Kyoto University
Publications - 65
Citations - 1696
Takeshi Aoyama is an academic researcher from Kyoto University. The author has contributed to research in topics: Percutaneous coronary intervention & Myocardial infarction. The author has an hindex of 19, co-authored 57 publications receiving 1540 citations. Previous affiliations of Takeshi Aoyama include Kyoto Prefectural University of Medicine & Community Medical Center.
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Journal ArticleDOI
Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I.
TL;DR: PGI2 stabilization by HDL and Apo A-I may be an important protective action against the accumulation of platelet thrombi at sites of vascular damage and the beneficial effect of HDL in the prevention of coronary artery disease may be partly due to this action.
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Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene
Kaoru Miyahara,Takeshi Kawamoto,Kazuhiro Sase,Yoshiki Yui,Katsumi Toda,Li-Xia Yang,Ryuichi Hattori,Takeshi Aoyama,Yasutake Yamamoto,Yoshinori Doi,Shohei Ogoshi,Kozo Hashimoto,Chuichi Kawai,Shigetake Sasayama,Yutaka Shizuta +14 more
TL;DR: Of particular interest is the fact that a shear-stress-responsive element is located at position -985, which probably regulates the nitric-oxide-synthase gene in response to fluid mechanical forces at the transcriptional level in the vascular endothelium.
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Excessive activation of matrix metalloproteinases coincides with left ventricular remodeling during transition from hypertrophy to heart failure in hypertensive rats
Yoshitaka Iwanaga,Takeshi Aoyama,Yasuki Kihara,Yoko Onozawa,Takeshi Yoneda,Shigetake Sasayama +5 more
TL;DR: Both TIMPs and MMP-2 remained inactive during hypertrophy, per se; they were activated during the transition to CHF, possibly resulting in ECM breakdown and progression of LV enlargement.
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Activation of TGF-β1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats
Madoka Matsumoto-Ida,Yoshihito Takimoto,Takeshi Aoyama,Masaharu Akao,Toshihiro Takeda,Toru Kita +5 more
TL;DR: Transforming growth factor-β1 alters myocardial gene expression, resulting in myocyte hypertrophy, through activation of TGF-β-activated kinase (TAK1), a member of the mitogen-activated pr...
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Long-term safety and efficacy of sirolimus-eluting stents versus bare-metal stents in real world clinical practice in Japan.
Takeshi Kimura,Takeshi Morimoto,Yutaka Furukawa,Yoshihisa Nakagawa,Kazushige Kadota,Masashi Iwabuchi,Satoshi Shizuta,Hiroki Shiomi,Tomohisa Tada,Junichi Tazaki,Yoshihiro Kato,Mamoru Hayano,Mitsuru Abe,Takashi Tamura,Manabu Shirotani,Shinji Miki,Mitsuo Matsuda,Mamoru Takahashi,Katsuhisa Ishii,Masaru Tanaka,Takeshi Aoyama,Osamu Doi,Ryuichi Hattori,Ryozo Tatami,Satoru Suwa,Akinori Takizawa,Yoshiki Takatsu,Masaaki Takahashi,Hiroshi Kato,Teruki Takeda,Jong Dae Lee,Ryuji Nohara,Hisao Ogawa,Chuwa Tei,Minoru Horie,Hirofumi Kambara,Hisayoshi Fujiwara,Kazuaki Mitsudo,Masakiyo Nobuyoshi,Toru Kita +39 more
TL;DR: SES-use as compared with BMS-use was associated with marked reduction of TLR without any increases in death, myocardial infarction, stent thrombosis, stroke and bleeding in real world clinical practice regardless of clinical presentation including AMI.