T
Takeshi Kubo
Researcher at University of Tsukuba
Publications - 6
Citations - 547
Takeshi Kubo is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Loss of heterozygosity & Endothelin receptor. The author has an hindex of 5, co-authored 6 publications receiving 535 citations.
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Journal Article
Loss of Heterozygosity on 10q23.3 and Mutation of the Tumor Suppressor Gene PTEN in Benign Endometrial Cyst of the Ovary: Possible Sequence Progression from Benign Endometrial Cyst to Endometrioid Carcinoma and Clear Cell Carcinoma of the Ovary
Nakako Sato,Hajime Tsunoda,Masato Nishida,Yukio Morishita,Yasuhiko Takimoto,Takeshi Kubo,Masayuki Noguchi +6 more
TL;DR: Results indicate that inactivation of the PTEN tumor suppressor gene is an early event in the development of ovarian endometrioid carcinoma and clear cell carcinoma of the ovary.
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Inactivation of p16/CDKN2 and p15/MTS2 genes in different histological types and clinical stages of primary ovarian tumors
Yoshihito Ichikawa,Sadao Yoshida,Yumi Koyama,Misako Hirai,Tomoyoshi Ishikawa,Masato Nishida,Hajime Tsunoda,Takeshi Kubo,Masanao Miwa,Kazuhiko Uchida +9 more
TL;DR: Results suggest that inactivation of p16/CDKN2 is potentially involved in the progression of ovarian tumors in advanced stages and p15/MTS2 may be the histological type‐specific events involved in ovarian tumorigenesis.
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Pregnancy increases ET-1-induced contraction and changes receptor subtypes in uterine smooth muscle in humans.
TL;DR: The present study suggests that, although (125)I-ET-1 Bmax are not altered during pregnancy, the proportion of ET(A) receptors is increased and that of ET[B] receptors is decreased in the pregnant human uterus.
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Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition.
Yoko Takanami-Ohnishi,Sachie Asada,Sachie Asada,Hajime Tsunoda,Akiyoshi Fukamizu,Katsutoshi Goto,Hiroyuki Yoshikawa,Takeshi Kubo,Tatsuhiko Sudo,Sadao Kimura,Yoshitoshi Kasuya +10 more
TL;DR: The results suggest that the p38 signaling pathway is involved in decidual function at the late stage of gestation and may contribute to parturition.
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Mechanism of rat uterine smooth muscle contraction induced by endothelin-1.
TL;DR: The present findings suggest that ET‐1‐induced contractile responses and the increase in oscillation frequency in rat uterine smooth muscle is mediated through ETA receptors, and that ETB receptors, play no role in these responses.