S
Sadao Kimura
Researcher at Chiba University
Publications - 150
Citations - 27055
Sadao Kimura is an academic researcher from Chiba University. The author has contributed to research in topics: Endothelin receptor & Endothelin 1. The author has an hindex of 56, co-authored 150 publications receiving 26612 citations. Previous affiliations of Sadao Kimura include Imperial College London & University of Tsukuba.
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Journal ArticleDOI
A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
Masashi Yanagisawa,Hiroki Kurihara,Hiroki Kurihara,Sadao Kimura,Yoko Tomobe,Mieko Kobayashi,Youji Mitsui,Yoshio Yazaki,Katsutoshi Goto,Tomoh Masaki +9 more
TL;DR: Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
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The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Akihiro Inoue,Masashi Yanagisawa,Sadao Kimura,Yoshitoshi Kasuya,Takashi Miyauchi,Katsutoshi Goto,Tomoh Masaki +6 more
TL;DR: Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endotheli sequence, suggesting the possible existence of endothelins receptor subtypes.
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Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor.
Takeshi Sakurai,Masashi Yanagisawa,Yoh Takuwa,Hitoshi Miyazaki,Sadao Kimura,Katsutoshi Goto,Tomoh Masaki +6 more
TL;DR: The cloning of a complementary DNA encoding one subtype belonging to the superf amily of G protein-coupled receptors is reported, indicating that this cDNA encodes a 'nonselective' subtype of the receptor which is different from the vascular smooth muscle receptor.
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Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension
Adel Giaid,Masashi Yanagisawa,David Langleben,René P. Michel,Robert D. Levy,Hani Shennib,Sadao Kimura,Tomoh Masaki,William P. Duguid,Duncan J. Stewart +9 more
TL;DR: Preliminary results suggest that pulmonary hypertension is associated with the increased expression of endothelin-1 in vascular endothelial cells, suggesting that the local production of endethelin- 1 may contribute to the vascular abnormalities associated with this disorder.
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Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.
Masashi Yanagisawa,Akihiro Inoue,Tomohisa Ishikawa,Yoshitoshi Kasuya,Sadao Kimura,S Kumagaye,Kazunori Nakajima,Takashi Watanabe,Shin Ichi Sakakibara,Katsutoshi Goto +9 more
TL;DR: This synthetic peptide had potent vasoconstrictor activity in the rat aortic strip and in perfused rat heart and a characteristically long-lasting in vivo pressor activity by intraaortic bolus injection in the conscious rat.