T
Takeshi Nagasaka
Researcher at Kawasaki Medical School
Publications - 171
Citations - 6484
Takeshi Nagasaka is an academic researcher from Kawasaki Medical School. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 37, co-authored 164 publications receiving 5698 citations. Previous affiliations of Takeshi Nagasaka include University of Calgary & Okayama University.
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Journal ArticleDOI
MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis
Keun Hur,Yuji Toiyama,Masanobu Takahashi,Francesc Balaguer,Takeshi Nagasaka,Junichi Koike,Hiromichi Hemmi,Minoru Koi,C. Richard Boland,Ajay Goel +9 more
TL;DR: The role of miR-200 members in the pathogenesis of metastatic colorectal cancer has not been investigated as mentioned in this paper, although the miR200 family is a crucial inhibitor of epithelial-to-mesenchymal transition (EMT) in human cancer.
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Serum miR-21 as a Diagnostic and Prognostic Biomarker in Colorectal Cancer
Yuji Toiyama,Masanobu Takahashi,Keun Hur,Takeshi Nagasaka,Koji Tanaka,Yasuhiro Inoue,Masato Kusunoki,C. Richard Boland,Ajay Goel +8 more
TL;DR: In this article, the expression profiles of circulating miRNAs reflect miRNA profiles of tumor tissues and to the best of our knowledge, no systematic investigation of the relationship between miRNA profile in body fluids vs matched primary colorectal cancer patients has been undertaken.
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Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Wenhao Weng,Wenhao Weng,Qing Wei,Shusuke Toden,Kazuhiro Yoshida,Takeshi Nagasaka,Toshiyoshi Fujiwara,Sanjun Cai,Huanlong Qin,Yanlei Ma,Ajay Goel +10 more
TL;DR: Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 and resulted in a more aggressive oncogenic phenotype, and ci RS-7 overexpression permitted the inhibition of mi R7 and subsequent activation of EGFR and RAF1 oncogenes.
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Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
Alexander Link,Francesc Balaguer,Francesc Balaguer,Yan Shen,Takeshi Nagasaka,Juan José Lozano,C. Richard Boland,Ajay Goel +7 more
TL;DR: The data indicate that miRNAs could be extracted from stool easily and reproducibly and may be an excellent candidate for the development of a noninvasive screening test for colorectal neoplasms.
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The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
Ajay Goel,Takeshi Nagasaka,Christian N. Arnold,Toru Inoue,Cody Hamilton,Donna Niedzwiecki,Carolyn C. Compton,Robert J. Mayer,Richard M. Goldberg,Monica M. Bertagnolli,C. Richard Boland +10 more
TL;DR: The findings suggest that CIN and CIMP represent 2 independent and inversely related mechanisms of genetic and epigenetic instability in sporadic CRCs and confirm that MSI cancers arise as a consequence of CIMp.