J
Juan José Lozano
Researcher at University of Barcelona
Publications - 236
Citations - 10396
Juan José Lozano is an academic researcher from University of Barcelona. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 52, co-authored 205 publications receiving 8292 citations. Previous affiliations of Juan José Lozano include Icahn School of Medicine at Mount Sinai & Pompeu Fabra University.
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Journal ArticleDOI
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
Toni Celià-Terrassa,Óscar Meca-Cortés,Francesca Mateo,Alexia Martínez de Paz,Nuria Rubio,Anna Arnal-Estapé,Brian Ell,Raquel Bermudo,Alba Díaz,Marta Guerra-Rebollo,Juan José Lozano,Conchi Estarás,Catalina Ulloa,Daniel ρlvarez-Simón,Jordi Mila,Ramon Vilella,Rosanna Paciucci,Marian A. Martínez-Balbás,Antonio García de Herreros,Roger R. Gomis,Yibin Kang,Jerónimo Blanco,Pedro L. Fernández,Timothy M. Thomson +23 more
TL;DR: Two human cellular models derived from prostate and bladder cancer provide new insights into how dynamic interactions among epithelial, self-renewal, and mesenchymal gene programs determine the plasticity of epithelial TICs.
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Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
Alexander Link,Francesc Balaguer,Francesc Balaguer,Yan Shen,Takeshi Nagasaka,Juan José Lozano,C. Richard Boland,Ajay Goel +7 more
TL;DR: The data indicate that miRNAs could be extracted from stool easily and reproducibly and may be an excellent candidate for the development of a noninvasive screening test for colorectal neoplasms.
Journal ArticleDOI
Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients
Marc Martinez-Llordella,Juan José Lozano,I. Puig-Pey,Giuseppe Orlando,Giuseppe Tisone,Jan Lerut,Carlos Benítez,José Antonio Pons,Pascual Parrilla,Pablo Ramírez,Miquel Bruguera,Antoni Rimola,Alberto Sanchez-Fueyo +12 more
TL;DR: It is suggested that transcriptional profiling of peripheral blood can be employed to identify liver transplant recipients who can discontinue immunosuppressive therapy and that innate immune cells are likely to play a major role in the maintenance of operational tolerance in liver transplantation.
Journal ArticleDOI
Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis
Francesc Balaguer,Alexander Link,Alexander Link,Juan José Lozano,Miriam Cuatrecasas,Takeshi Nagasaka,C. Richard Boland,Ajay Goel +7 more
TL;DR: The data indicate that miR-137 acts as a tumor suppressor in the colon and is frequently silenced by promoter hypermethylation, which suggests it to be an early event, which has prognostic and therapeutic implications.
Journal ArticleDOI
DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.
Manuel J. Muñoz,M. Soledad Pérez Santangelo,Maria Paola Paronetto,Manuel de la Mata,Federico Pelisch,Stéphanie Boireau,Kira Glover-Cutter,Claudia Ben-Dov,Matías Blaustein,Juan José Lozano,Gregory H. Bird,David Bentley,Edouard Bertrand,Alberto R. Kornblihtt +13 more
TL;DR: It is shown that ultraviolet irradiation affects cotranscriptional AS in a p53-independent way, through the hyperphosphorylation of RNA polymerase II carboxy-terminal domain (CTD) and a subsequent inhibition of transcriptional elongation, estimated in vivo and in real time.