Organic synthesis at high pressure

TLDR: In this article, the authors recommend that all synthetic chemists should always consider pressure as one of the routine variables available to them, along with temperature, solvent, reaction time, catalysts, and so forth.

Abstract: The recommendation is developed that all synthetic chemists should always consider pressure as one of the routine variables available to them, along with temperature, solvent, reaction time, catalysts, and so forth. Ideally, equipment should be available both in the 1–5 and 10–20 kbar range, the former for the habitual testing of all reaction steps under increased pressure, and the latter for the more unusual instances in which gigapascal pressures appear to force otherwise reluctant reactions. The hope is that synthetic chemists will learn to optimize yields and conversions with respect to pressure as well as the other variables, and to report the pressure used just as routinely as they report reaction times and temperatures now.