T
Takeshi Todoroki
Researcher at University of Tsukuba
Publications - 115
Citations - 2587
Takeshi Todoroki is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Cancer & Gallbladder. The author has an hindex of 29, co-authored 114 publications receiving 2519 citations.
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Journal ArticleDOI
Benefits of adjuvant radiotherapy after radical resection of locally advanced main hepatic duct carcinoma
Takeshi Todoroki,Kiyoshi Ohara,Toru Kawamoto,N Koike,Sadao Yoshida,Hironobu Kashiwagi,Masaaki Otsuka,Katashi Fukao +7 more
TL;DR: The data clearly suggest the improved prognosis of patients with locally advanced Klatskin tumor by integrated adjuvant radiotherapy with IORT and PORT to complete gross tumor resection with acceptable treatment mortality and morbidity.
Journal Article
Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 Genes in Biliary Tract Cancers
Sadao Yoshida,Takeshi Todoroki,Yoshihito Ichikawa,Shuji Hanai,Hiromichi Suzuki,Mitsuo Hori,Katashi Fukao,Masanao Miwa,Kazuhiko Uchida +8 more
TL;DR: Results suggest that p16Ink4/CDKN2, rather than p15InK4B/MTS2 or p53 genes, and its inactivation may be important in biliary tract carcinogenesis.
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Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand.
Satoshi Honjo,Petcharin Srivatanakul,Hutcha Sriplung,Hiroko Kikukawa,Shuji Hanai,Kazuhiko Uchida,Takeshi Todoroki,Adisorn Jedpiyawongse,Pacharin Kittiwatanachot,Banchob Sripa,Somyos Deerasamee,Masanao Miwa +11 more
TL;DR: Infection with OV correlates strongly with cholangiocarcinoma, susceptibility to which may be possibly associated with GSTM1 polymorphism, and alcohol may affect metabolic pathways of endogenous and exogenous nitrosamines.
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Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1
Takeshi Gohongi,Dai Fukumura,Yves Boucher,Chae-Ok Yun,Gerald A. Soff,Carolyn C. Compton,Takeshi Todoroki,Rakesh K. Jain +7 more
TL;DR: It is shown here that the gallbladder microenvironment modulates the production of transforming growth factor (TGF)-β1, a multifunctional cytokine that functions as an endogenous anti-angiogenic and anti-tumor factor in a cranial window preparation.
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Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramide
Kazuhiko Yanagisawa,Ken-ichiro Seino,Yuriko Ishikawa,Mutsumi Nozue,Takeshi Todoroki,Katashi Fukao +5 more
TL;DR: It is found that Vα24 NKT cells in unfractionated PBMCs obtained from cancer patients did not respond efficiently to α-galactosylceramide (α-GalCer) in vitro, and this observation carries significant implications for immunotherapy-based cancer treatments.