K
Ken-ichiro Seino
Researcher at Hokkaido University
Publications - 145
Citations - 5164
Ken-ichiro Seino is an academic researcher from Hokkaido University. The author has contributed to research in topics: Immune system & Natural killer T cell. The author has an hindex of 40, co-authored 137 publications receiving 4653 citations. Previous affiliations of Ken-ichiro Seino include Juntendo University & Institute of Medical Science.
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Antitumor effect of locally produced CD95 ligand
TL;DR: Investigation of the antitumor effect of locally produced CD95 ligand (CD95L) on CD95-negative tumor cells in vivo provides evidence for the potential utility of CD95L in tumor eradication and reveals a proinflammatory function of CD 95L.
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Requirement for natural killer T (NKT) cells in the induction of allograft tolerance.
Ken-ichiro Seino,Katashi Fukao,Kenzo Muramoto,Kazuhiko Yanagisawa,Yasutsugu Takada,Shigeru Kakuta,Yoichiro Iwakura,Luc Van Kaer,Kazuyoshi Takeda,Toshinori Nakayama,Masaru Taniguchi,Hisashi Bashuda,Hideo Yagita,Ko Okumura +13 more
TL;DR: A critical contribution of Vα14 NKT cells to the induction of allograft tolerance is indicated and experiments using IL-4- or IFN-γ-deficient mice provide a useful model to investigate the regulatory role of V α14 N KT cells in various immune responses.
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The NKT cell system: bridging innate and acquired immunity
TL;DR: Closer examination indicates that recognition of endogenous ligands and interleukin 12, rather than bacterial products, may drive the activation process.
Journal Article
Chemotactic activity of soluble Fas ligand against phagocytes
Ken-ichiro Seino,Kazuhisa Iwabuchi,Nobuhiko Kayagaki,Ryukou Miyata,Isao Nagaoka,Akio Matsuzawa,Katashi Fukao,Hideo Yagita,Ko Okumura +8 more
TL;DR: Results directly indicated a chemotactic activity of sFasL against PMN and suggest a novel signaling function of Fas, which appears to be independent of the death domain-mediated apoptosis.
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Generation of Cloned Mice by Direct Nuclear Transfer from Natural Killer T Cells
Kimiko Inoue,Hiroshi Wakao,Narumi Ogonuki,Hiromi Miki,Ken-ichiro Seino,Rika Nambu-Wakao,Shinichi Noda,Hiroyuki Miyoshi,Haruhiko Koseki,Masaru Taniguchi,Atsuo Ogura +10 more
TL;DR: It is shown that the genome of a unique T-cell population, natural killer T (NKT) cells, can be fully reprogrammed by a single-step NT and postulate that at least some mammals cloned to date have indeed been derived from differentiated donor cells.