T
Takuya Watanabe
Researcher at Fukuoka University
Publications - 64
Citations - 1110
Takuya Watanabe is an academic researcher from Fukuoka University. The author has contributed to research in topics: Neurotransmission & Excitatory postsynaptic potential. The author has an hindex of 15, co-authored 57 publications receiving 851 citations. Previous affiliations of Takuya Watanabe include University of Massachusetts Medical School.
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Journal ArticleDOI
Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia
Noriko Sumi,Tsuyoshi Nishioku,Fuyuko Takata,Junichi Matsumoto,Takuya Watanabe,Hideki Shuto,Atsushi Yamauchi,Shinya Dohgu,Yasufumi Kataoka +8 more
TL;DR: The present findings suggest that LPS activates microglia to induce dysfunction of the BBB by producing reactive oxygen species through NADPH oxidase.
Journal ArticleDOI
Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture
Marta Esteves da Silva,Max Adrian,Philipp Schätzle,Joanna Lipka,Joanna Lipka,Takuya Watanabe,Sukhee Cho,Kensuke Futai,Corette J. Wierenga,Lukas C. Kapitein,Lukas C. Kapitein,Casper C. Hoogenraad,Casper C. Hoogenraad +12 more
TL;DR: It is shown that intracellular AMPARs are transported in Rab11-positive recycling endosomes, which frequently enter dendritic spines and depend on the microtubule and actin cytoskeleton, and a mechanistic link between endosome positioning and postsynaptic structure and composition is suggested.
Journal ArticleDOI
Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4
Takuya Watanabe,Shinya Dohgu,Fuyuko Takata,Tsuyoshi Nishioku,Akio Nakashima,Koujiro Futagami,Atsushi Yamauchi,Yasufumi Kataoka +7 more
TL;DR: Results suggest that bEND.3 cells are a convenient and useful model for evaluating BBB function, especially the paracellular barrier, as well as those of the primary mouse brain endothelial cells pMBECs.
Journal ArticleDOI
Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease
Takuya Watanabe,Norito Yamagata,Kotaro Takasaki,Kazunori Sano,Kazuhide Hayakawa,Shutaro Katsurabayashi,Nobuaki Egashira,Kenichi Mishima,Katsunori Iwasaki,Michihiro Fujiwara +9 more
TL;DR: Memory impairment in Tg mice could be attributed to cholinergic synapse dysfunction that could not be caused predominantly by amyloid plaques, and measuring ACh release in this model might be a useful index for the screening of new drugs to treat the early-phase of Alzheimer's disease.
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Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice
Nobuaki Egashira,Katsunori Iwasaki,Akihiko Takashima,Takuya Watanabe,Hideyuki Kawabe,Tomomi Matsuda,Kenichi Mishima,Shozo Chidori,Ryoji Nishimura,Michihiro Fujiwara +9 more
TL;DR: It is suggested that R406W Tg mice exhibit changes in depression-related behavior involving serotonergic neurons and provide an animal model for investigating AD with depression.