Tammy Price-Troska

TL;DR: In this paper, an integrated analysis of high-density oligonucleotide array CGH and gene expression profiling data from 155 multiple myeloma samples identified a promiscuous array of abnormalities contributing to the dysregulation of NF-kappaB in approximately 20% of patients.

TL;DR: Overall pPCL and sPCL are different disorders with distinct natural histories, genetics and survival, and both show frequent N-RAS or K-Ras mutation.

TL;DR: It is shown that H-MM is defined by a protein biosynthesis signature that is primarily driven by a gene dosage mechanism as a result of trisomic chromosomes that may provide a basis for tailoring treatment to individual patients.

TL;DR: In this article, the authors characterized the repertoire of immunoglobulin light chain variable genes used by the clonal B cell in light chain-associated amyloidosis (AL) patients, and the association of light-chain variable region (VL) genes with clinical presentation and outcome was assessed in 58 (32 lambda and 26 kappa) patients.

TL;DR: Both 1q21 gain and increase gene expression level were significantly associated with reduced survival in multiple myeloma, however, neither is an independent prognostic marker in MM on multivariate Cox proportional hazard analysis.