Tanara V. Peres

TL;DR: It is reported that exposure to Mn may arise from environmental sources, occupational settings, food, total parenteral nutrition (TPN), methcathinone drug abuse or even genetic factors, such as mutation in the transporter SLC30A10.

TL;DR: This review advocates revisiting the current safety and regulation of specific sunscreens and investing in alternative UV protection technologies, including zinc oxide and titanium dioxide.

TL;DR: It is shown that long-term exposure to Mn during a critical period of neurodevelopment causes motor coordination dysfunction with parallel increment in oxidative stress markers, p38MAPK phosphorylation and caspase activity in the striatum and Trolox is established as a potential neuroprotective agent given its efficacy in reversing the Mn-induced neurodevelopmental effects.

TL;DR: Investigating the developmental neurotoxicity in an in vivo model of immature rats exposed to Mn from postnatal day 8 to PN12 establishes that short-term exposure to Mn during a specific developmental window induces metabolic and neurochemical alterations in the striatum that may modulate later-life behavioral changes.

TL;DR: This review will address recent progress in Mn-induced neurotoxicity from C. elegans to humans, and explore future directions that will help understand the mechanisms of its neurotoxicity.