T
Tanya Armstrong
Researcher at Murdoch University
Publications - 8
Citations - 686
Tanya Armstrong is an academic researcher from Murdoch University. The author has contributed to research in topics: Trypanosoma cruzi & Chagas disease. The author has an hindex of 5, co-authored 8 publications receiving 607 citations. Previous affiliations of Tanya Armstrong include University of Western Australia & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
In vitro and in vivo experimental models for drug screening and development for Chagas disease
Alvaro J. Romanha,Solange L. de Castro,Maria de Nazaré Correia Soeiro,Joseli Lannes-Vieira,Isabela Ribeiro,André Talvani,Bernadette Bourdin,Bethania Blum,Bianca P. Olivieri,Carlos L. Zani,Carmenza Spadafora,Egler Chiari,Eric Chatelain,Gabriela Costa Chaves,José E. Calzada,Juan M. Bustamante,Lucio H. Freitas-Junior,Luz Romero,Maria Terezinha Bahia,Michel Lotrowska,Milena Botelho Pereira Soares,Sonia G. Andrade,Tanya Armstrong,Wim Degrave,Zilton A. Andrade +24 more
TL;DR: An in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease.
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Loop-Mediated Isothermal Amplification (LAMP) Method for Rapid Detection of Trypanosoma brucei rhodesiense
Z.K. Njiru,Andrew Mikosza,Tanya Armstrong,John Enyaru,Joseph Mathu Ndung'u,Andrew R. C. Thompson +5 more
TL;DR: A LAMP test was designed from the serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense, the cause of the acute form of African sleeping sickness, and used to detect parasite DNA from processed and heat-treated infected blood samples.
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Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease
Martine Keenan,Michael J. Abbott,Paul W. Alexander,Tanya Armstrong,Wayne M. Best,Bradley Berven,Adriana Botero,Jason H. Chaplin,Susan A. Charman,Eric Chatelain,Thomas W. von Geldern,Maria Kerfoot,Andrea Khong,Tien Nguyen,Joshua D. McManus,Julia Morizzi,Eileen Ryan,Ivan Scandale,R.C. Andrew Thompson,Sen Z. Wang,Karen L. White +20 more
TL;DR: Compounds are chemically tractable, allowing rapid optimization of target biological activity and drug characteristics, and suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection.
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Morphological characterization of Cryptosporidium parvum life-cycle stages in an in vitro model system.
TL;DR: The complete life cycle of C. parvum is described in an in vitro system and its morphology, development and behavioural characteristics are visualized and morphologically characterized for the first time using scanning electron microscopy.
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Target validation of the inosine monophosphate dehydrogenase (IMPDH) gene in Cryptosporidium using Phylomer® peptides
R. Jefferies,R. Jefferies,Rongchang Yang,C.K. Woh,C.K. Woh,T. Weldt,Nadia Milech,A. Estcourt,Tanya Armstrong,Richard Hopkins,Paul M. Watt,Simon Reid,Anthony Armson,Una Ryan +13 more
TL;DR: The present study highlights the potential of Phylomer peptides as target validation tools for Cryptosporidium and other organisms and diseases because of their ability to bind with high affinity to target proteins and disrupt function.