T
Tarik F. Haydar
Researcher at Boston University
Publications - 62
Citations - 8012
Tarik F. Haydar is an academic researcher from Boston University. The author has contributed to research in topics: Neurogenesis & Neocortex. The author has an hindex of 37, co-authored 59 publications receiving 7235 citations. Previous affiliations of Tarik F. Haydar include Children's National Medical Center & George Washington University.
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Journal ArticleDOI
Reduced Apoptosis and Cytochrome c-Mediated Caspase Activation in Mice Lacking Caspase 9
Keisuke Kuida,Tarik F. Haydar,Chia-Yi Kuan,Yong Gu,Choji Taya,Hajime Karasuyama,Michael S.-S. Su,Pasko Rakic,Richard A. Flavell +8 more
TL;DR: Results indicate that Casp9 is a critical upstream activator of the caspase cascade in vivo, as indicated by the absence of Casp3-like cleavage and the restoration of cytochrome c-mediated cleavage after addition of in vitro-translated Casp 9.
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Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Hirohide Asai,Seiko Ikezu,Satoshi Tsunoda,Maria Medalla,Jennifer I. Luebke,Tarik F. Haydar,Benjamin Wolozin,Oleg Butovsky,Sebastian Kügler,Tsuneya Ikezu +9 more
TL;DR: It is found that depleting microglia dramatically suppressed the propagation of tau and reduced excitability in the dentate gyrus in this mouse model, and this data suggest that microglian involvement in tau propagation and the exosome secretion pathway may be a therapeutic target.
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Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors.
TL;DR: It is found that GABAA receptors are tonically activated in GFAP-expressing cells, consistent with the presence of spontaneous depolarizations in neuroblasts that are sufficient to induce GABA release, and this data demonstrate the existence of nonsynaptic GABAergic signaling between neuroblast and GFAPS cells.
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Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
TL;DR: The relative contributions of the VZ and SVZ to neocortical growth may be regulated by differential responsiveness to GABA and glutamate, which are implicated in the regulation of neural progenitor proliferation.
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Molecular and Morphological Heterogeneity of Neural Precursors in the Mouse Neocortical Proliferative Zones
Jonathan S. Gal,Yury M. Morozov,Albert E. Ayoub,Mitali Chatterjee,Pasko Rakic,Tarik F. Haydar +5 more
TL;DR: The present study indicates that the VZ in murine dorsal telencephalon is similar to that in human and nonhuman primates, because it contains multiple types of neuronal precursors.