T
Tatiana Nikitina
Researcher at University of Massachusetts Amherst
Publications - 14
Citations - 1869
Tatiana Nikitina is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 13, co-authored 14 publications receiving 1755 citations. Previous affiliations of Tatiana Nikitina include National Institutes of Health.
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Journal ArticleDOI
Histone H1 Depletion in Mammals Alters Global Chromatin Structure but Causes Specific Changes in Gene Regulation
Yuhong Fan,Tatiana Nikitina,Jie Zhao,Tomara J. Fleury,Riddhi Bhattacharyya,Eric E. Bouhassira,Arnold Stein,Christopher L. Woodcock,Arthur I. Skoultchi +8 more
TL;DR: Results indicate that linker histones can participate in epigenetic regulation of gene expression by contributing to the maintenance or establishment of specific DNA methylation patterns.
Journal ArticleDOI
H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo.
Yuhong Fan,Tatiana Nikitina,Elizabeth M. Morin-Kensicki,Jie Zhao,Terry Magnuson,Christopher L. Woodcock,Arthur I. Skoultchi +6 more
TL;DR: It is demonstrated that the total amount of H1 is crucial for proper embryonic development and inactivating the genes for three mouse H1 subtypes showed that linker histones are essential for mammalian development.
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Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.
Tatiana Nikitina,Xi Shi,Rajarshi P. Ghosh,Rachel A. Horowitz-Scherer,Jeffrey C. Hansen,Christopher L. Woodcock +5 more
TL;DR: All of the RTT-inducing mutants tested were quantitatively bound to chromatin under the authors' conditions, but those that tend to be associated with the more severe RTT symptoms failed to induce the extensive compaction observed with wild-type MeCP2.
Journal ArticleDOI
Closed chromatin loops at the ends of chromosomes
TL;DR: Electron microscopy reveals telomere chromatin fibers in the form of closed terminal loops, which correspond to the “t-loop” structures adopted by telomeres DNA.
Journal ArticleDOI
MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites
Rajarshi P. Ghosh,Rachel A. Horowitz-Scherer,Tatiana Nikitina,Luda S. Shlyakhtenko,Christopher L. Woodcock +4 more
TL;DR: It is shown that strong methylation-independent as well asmethylation-dependent binding by MeCP2 is influenced by DNA length, which suggests that chromatin binding byMeCP2 and H1 in vivo should be viewed in the context of competitive multifactorial regulation.