T
Tatjana Paunesku
Researcher at Northwestern University
Publications - 54
Citations - 2627
Tatjana Paunesku is an academic researcher from Northwestern University. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 21, co-authored 46 publications receiving 2496 citations. Previous affiliations of Tatjana Paunesku include Argonne National Laboratory & Loyola University Medical Center.
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Journal ArticleDOI
DNA sequence determination by hybridization: A strategy for efficient large-scale sequencing
Radoje Drmanac,Snezana Drmanac,Z. Strezoska,Z. Strezoska,Tatjana Paunesku,Ivan Labat,Ivan Labat,M. Zeremski,M. Zeremski,J. Snoddy,W. K. Funkhouser,Ben F. Koop,Ben F. Koop,Leroy Hood,Leroy Hood,R. Crkvenjakov +15 more
TL;DR: The concept of sequencing by hybridization (SBH) makes use of an array of all possible n-nucleotide oligomers (n-mers) to identify n-mers present in an unknown DNA sequence and may accelerate the mapping and sequencing phases of the human genome project.
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Proliferating Cell Nuclear Antigen (PCNA): Ringmaster of the Genome
Tatjana Paunesku,S. Mittal,Miroslava Protic,J. Oryhon,Sergey Korolev,Andrzej Joachimiak,Gayle E. Woloschak +6 more
TL;DR: The evolution from prokaryotes to eukaryotes involved a change of function of PCNA from a 'simple' sliding clamp protein of the DNA polymerase complex to an executive molecule controlling critical cellular decision pathways.
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Biology of TiO2-oligonucleotide nanocomposites.
Tatjana Paunesku,Tijana Rajh,Gary P. Wiederrecht,Jörg Maser,Stefan Vogt,Nataša Stojićević,Nataša Stojićević,Miroslava Protic,Barry Lai,Jeremy Oryhon,Marion C. Thurnauer,Gayle E. Woloschak,Gayle E. Woloschak +12 more
TL;DR: The behaviour of 45-Å nanoparticles of titanium dioxide semiconductor combined with oligonucleotide DNA into nanocomposites in vivo and in vitro are described, which possess the chemically and biologically unique new property of a light-inducible nucleic acid endonuclease, which could become a new tool for gene therapy.
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X‐ray fluorescence microprobe imaging in biology and medicine
TL;DR: Characteristic X‐ray fluorescence is a technique that can be used to establish elemental concentrations for a large number of different chemical elements simultaneously in different locations in cell and tissue samples to gain insight into cellular processes.
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DNA sequencing by hybridization: 100 bases read by a non-gel-based method.
TL;DR: The technological components of large-scale DNA sequencing using the sequencing by hybridization method are in place and the hybridization pattern obtained enabled us to resequence the 100 base pairs by applying an algorithm that tolerates an error rate much higher than was observed in the experiment.