S
Sergey Korolev
Researcher at Saint Louis University
Publications - 75
Citations - 4800
Sergey Korolev is an academic researcher from Saint Louis University. The author has contributed to research in topics: DNA & DNA repair. The author has an hindex of 28, co-authored 69 publications receiving 4433 citations. Previous affiliations of Sergey Korolev include Russian Academy of Sciences & Engelhardt Institute of Molecular Biology.
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Journal ArticleDOI
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation
TL;DR: These structures provide the first direct evidence in DNA polymerase I enzymes of a large conformational change responsible for assembling an active ternary complex.
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Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP.
TL;DR: Crystal structures of binary and ternary complexes of the E. coli Rep helicase bound to single-stranded DNA or ssDNA and ADP were determined to a resolution of 3.0 A to suggest that these may be coupled to translocation of the Rep dimer along DNA.
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Mutations in Cohesin Complex Members SMC3 and SMC1A Cause a Mild Variant of Cornelia de Lange Syndrome with Predominant Mental Retardation
Matthew A. Deardorff,Matthew A. Deardorff,Maninder Kaur,Dinah Yaeger,Abhinav Rampuria,Sergey Korolev,Juan Pié,Concepcion Gil-Rodríguez,María Teresa Echeverría Arnedo,Bart Loeys,Antonie D. Kline,Meredith Wilson,Kaj Lillquist,Victoria Mok Siu,Feliciano J. Ramos,Antonio Musio,Laird S. Jackson,Dale Dorsett,Ian D. Krantz,Ian D. Krantz +19 more
TL;DR: The authors' data indicate that SMC3 and SMC1A mutations contribute to approximately 5% of cases of CdLS, result in a consistently mild phenotype with absence of major structural anomalies typically associated with Cd LS, and in some instances, result with a phenotype that approaches that of apparently nonsyndromic mental retardation.
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Proliferating Cell Nuclear Antigen (PCNA): Ringmaster of the Genome
Tatjana Paunesku,S. Mittal,Miroslava Protic,J. Oryhon,Sergey Korolev,Andrzej Joachimiak,Gayle E. Woloschak +6 more
TL;DR: The evolution from prokaryotes to eukaryotes involved a change of function of PCNA from a 'simple' sliding clamp protein of the DNA polymerase complex to an executive molecule controlling critical cellular decision pathways.
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Structure of the RPA trimerization core and its role in the multistep DNA‐binding mechanism of RPA
TL;DR: The data indicate that switching from 8–10 to 30 nt mode is mediated by DNA binding with the trimerization core, and this work demonstrates that the OB‐fold of DBD‐C possesses unique structural features; embedded zinc ribbon and helix–turn–helix motifs.