Shengdian Wang

TL;DR: It is reported here that constitutive or inducible expression of B7-H1, a B7 family molecule widely expressed by cancers, confers resistance to therapeutic anti-CD137 antibody in mice with established tumors and implicate new approaches for immunotherapy of human cancers.

TL;DR: A B7 family molecule, B7-H4, is identified by protein sequence analysis and comparative molecular modeling and may participate in negative regulation of cell-mediated immunity in peripheral tissues.

TL;DR: It is demonstrated that the mechanisms of tumor regression by anti-HER2/neu antibody therapy also require the adaptive immune response, and the addition of chemotherapeutic drugs, although capable of enhancing the reduction of tumor burden, could abrogate antibody-initiated immunity leading to decreased resistance to rechallenge or earlier relapse.

TL;DR: The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule.

TL;DR: This work finds that nonconserved residues between these ligands on the A′GFCC′C′′ face mediate interaction with PD-1, indicating significant structural heterogeneity of the interactions between PD-2 and its ligands and providing direct evidence for an independent costimulatory receptor other than PD- 1.