T
Tauno Metsalu
Researcher at University of Tartu
Publications - 9
Citations - 3080
Tauno Metsalu is an academic researcher from University of Tartu. The author has contributed to research in topics: Cell culture & Gene expression. The author has an hindex of 7, co-authored 8 publications receiving 2000 citations.
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Journal ArticleDOI
ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap
Tauno Metsalu,Jaak Vilo +1 more
TL;DR: A web tool called ClustVis that aims to have an intuitive user interface for the Principal Component Analysis and heatmap plots and is freely available at http://biit.cs.ut.ee/clustvis/.
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MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data.
TL;DR: The MethSurv tool is a valuable platform for the researchers without programming skills to perform the initial assessment of methylation-based cancer biomarkers.
Journal ArticleDOI
A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response
George Sflomos,Valérian Dormoy,Tauno Metsalu,Rachel Jeitziner,Laura Battista,Valentina Scabia,Wassim Raffoul,Jean-François Delaloye,Assya Treboux,Maryse Fiche,Jaak Vilo,Ayyakkannu Ayyanan,Cathrin Brisken +12 more
TL;DR: It is shown that the traditional grafting of ER⁺ tumor cells into mammary fat pads induces TGFβ/SLUG signaling and basal differentiation when they require low SLUG levels to grow in vivo.
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Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis
Ana Rebane,Ana Rebane,Maya Zimmermann,Alar Aab,Hansjörg Baurecht,Andrea Koreck,Maire Karelson,Kristi Abram,Tauno Metsalu,Maire Pihlap,Norbert Meyer,Regina Fölster-Holst,Nikoletta Nagy,Nikoletta Nagy,Lajos Kemény,Lajos Kemény,Külli Kingo,Külli Kingo,Jaak Vilo,Thomas Illig,Mübeccel Akdis,Andre Franke,Natalija Novak,Stephan Weidinger,Cezmi A. Akdis +24 more
TL;DR: The results demonstrate increased IFN-γ responses in skin of patients with AD and suggest involvement of multiple new apoptosis- and inflammation-related factors in the development of AD.
Journal ArticleDOI
Capturing complex tumour biology in vitro: Histological and molecular characterisation of precision cut slices
Emma J. Davies,Meng Dong,Matthias Gutekunst,Katja Närhi,Hanneke J. A. A. van Zoggel,Sami Blom,Ashwini S. Nagaraj,Tauno Metsalu,Eva Oswald,Sigrun Erkens-Schulze,Juan A. Delgado San Martin,Riku Turkki,Stephen R. Wedge,Taija af Hällström,Julia Schueler,Wytske M. van Weerden,Emmy W. Verschuren,Simon T. Barry,Heiko van der Kuip,John A. Hickman +19 more
TL;DR: A standardised workflow for systematic comparison of tumour slice cultivation methods and a tissue microarray-based method to archive them is described, with recognition of temporal-spatial changes in protein expression before interrogation of tumours slices by pharmacological or other means.