W
Wassim Raffoul
Researcher at University of Lausanne
Publications - 204
Citations - 5149
Wassim Raffoul is an academic researcher from University of Lausanne. The author has contributed to research in topics: Medicine & Progenitor cell. The author has an hindex of 31, co-authored 176 publications receiving 4212 citations. Previous affiliations of Wassim Raffoul include University Hospital of Lausanne.
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Journal ArticleDOI
Adipose-derived stem cells enhance peripheral nerve regeneration
P.G. di Summa,P.G. di Summa,Paul J. Kingham,Paul J. Kingham,Wassim Raffoul,Mikael Wiberg,Giorgio Terenghi,Daniel F. Kalbermatten,Daniel F. Kalbermatten +8 more
TL;DR: It is suggested that adipose-derived stem cells may provide an effective cell population, without the limitations of the donor-site morbidity associated with isolation of Schwann cells, and could be a clinically translatable route towards new methods to enhance peripheral nerve repair.
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Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism
Ayyakannu Ayyanan,Gianluca Civenni,Laura Ciarloni,Catherine Morel,Nathalie Mueller,Karine Lefort,Anna Mandinova,Wassim Raffoul,Maryse Fiche,G P Dotto,Cathrin Brisken +10 more
TL;DR: It is reported that increased Wnt signaling, as achieved by ectopic expression of Wnt-1, triggers the DNA damage response (DDR) and an ensuing cascade of events resulting in tumorigenic conversion of primary human mammary epithelial cells.
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Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases
Karine Lefort,Anna Mandinova,Paola Ostano,Vihren N. Kolev,Valérie Calpini,Ingrid Kolfschoten,Vikram Devgan,Jocelyn Lieb,Wassim Raffoul,Daniel Hohl,Victor A. Neel,Jonathan Garlick,Giovanna Chiorino,G. Paolo Dotto +13 more
TL;DR: The Notch1 gene is a p53 target with a role in human tumor suppression through negative regulation of Rho effectors, with expression of this gene being under p53 control in keratinocyte cancer cell lines and tumors.
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Progesterone/RANKL is a major regulatory axis in the human breast.
Tamara Tanos,George Sflomos,Pablo Christian Echeverria,Ayyakkannu Ayyanan,Maria Gutierrez,Jean-François Delaloye,Wassim Raffoul,Maryse Fiche,William C. Dougall,Pascal Schneider,Ozden Yalcin-Ozuysal,Cathrin Brisken +11 more
TL;DR: Ex vivo model identifies the progesterone/RANKL axis as an important proliferative stimulus in the human breast and finds that important hormonal control mechanisms are conserved across species, making RANKL a potential target in breast cancer treatment and prevention.
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Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts
P.G. di Summa,Daniel F. Kalbermatten,Daniel F. Kalbermatten,Etienne Pralong,Wassim Raffoul,Paul J. Kingham,Paul J. Kingham,Giorgio Terenghi +7 more
TL;DR: DASC were the most effective cell population in terms of improvement of axonal and fiber diameter, evoked potentials at the level of the gastrocnemius muscle and regeneration of motoneurons, similar to the autografts.