T
Ted A. Laurence
Researcher at Lawrence Livermore National Laboratory
Publications - 110
Citations - 6242
Ted A. Laurence is an academic researcher from Lawrence Livermore National Laboratory. The author has contributed to research in topics: Fluorescence correlation spectroscopy & Laser. The author has an hindex of 35, co-authored 102 publications receiving 5746 citations. Previous affiliations of Ted A. Laurence include University of California, Los Angeles & University of California, Santa Barbara.
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Journal ArticleDOI
Fluorescence-aided molecule sorting: Analysis of structure and interactions by alternating-laser excitation of single molecules
TL;DR: FAMS is a general platform for ratiometric measurements that report on structure, dynamics, stoichiometries, environment, and interactions of diffusing or immobilized molecules, thus enabling detailed mechanistic studies and ultrasensitive diagnostics.
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Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2.
Ashok A. Deniz,Ted A. Laurence,Gangamani S. Beligere,Maxime Dahan,Andrew B. Martin,Daniel S. Chemla,Philip E. Dawson,Peter G. Schultz,Shimon Weiss +8 more
TL;DR: It is shown that new information about different aspects of the protein folding reaction can be extracted from such subpopulation properties, and shifts in the mean transfer efficiencies, FRET efficiency distributions, and denaturation curves are discussed.
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Time-gated biological imaging by use of colloidal quantum dots.
Maxime Dahan,Ted A. Laurence,Fabien Pinaud,Daniel S. Chemla,A. P. Alivisatos,Markus Sauer,Shimon Weiss +6 more
TL;DR: The long (but not too long) fluorescence lifetime of CdSe semiconductor quantum dots was exploited to enhance fluorescence biological imaging contrast and sensitivity by time-gated detection.
Journal ArticleDOI
Alternating-laser excitation of single molecules.
Achillefs N. Kapanidis,Ted A. Laurence,Nam Ki Lee,Emmanuel Margeat,Xiangxu Kong,Shimon Weiss +5 more
TL;DR: A new family of single-molecule fluorescence methods that uses alternating-laser excitation of diffusing or immobilized biomolecules to study their structure, interactions, and dynamics are described.
Journal ArticleDOI
Shot-Noise Limited Single-Molecule FRET Histograms: Comparison between Theory and Experiments†
Eyal Nir,Xavier Michalet,Kambiz M. Hamadani,Ted A. Laurence,Daniel Neuhauser,Yevgeniy Kovchegov,Shimon Weiss +6 more
TL;DR: A straightforward numerical algorithm is presented to compute the best fit shot-noise limited proximity ratio histogram (PRH) in single-molecule fluorescence resonant energy transfer diffusion experiments, and it is found that dsDNA data exhibit a wider PRH than expected from shot noise only.