Teresa Bellón

TL;DR: A novel inhibitory MHC class I receptor of the immunoglobulin-superfamily is characterized, expressed not only by subsets of NK and T cells, but also by B cells, monocytes, macrophages, and dendritic cells, suggesting that diverse leukocyte lineages have adopted recognition of self–MHC class II molecules as a common strategy to control cellular activation during an immune response.

TL;DR: It is found that HLA-A*31:01 is a specific predictor for CBZ-DRESS but not forCBZ-SJS/TEN in Europeans, and the cost-effectiveness of the combined Hla-A*,15:02 genetic test to prevent CBz-SCAR in Chinese needs further investigation.

TL;DR: NK cells recognize several HLA class Ib molecules employing both immunoglobulin-like (Ig-like) and C-type lectin receptors, and the KIR2DL4 (p49) receptor has been shown to specifically recognize HLA-G1.

TL;DR: Data support the idea that the CD94/NKG2 receptor complex is involved in the recognition of cells expressing HLA-G1, and suggest that anti-HLA class I mAbs reconstituted their cytolytic activity comparably to anti- HLA class II mAbs.

TL;DR: The identification of a novel molecule (DAP12) with a key role in the activation pathways; the observation that certain immunoglobulin-like receptors for HLA class I molecules are also utilized by other leucocyte lineages; and the definition of MHC class Ib proteins (i.e. HLA-E and Qa-1b) as specific ligands for the phylogenetically conserved CD94-NKG2 lectin- like receptors.